Treatment | Mytilus edulis, protein hydrolyzate | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||||||||||||||||||||
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CID (PubChem) | 5282253 | ChEMBL | locomotion on solid media | body length / growth rate | heat stress resistance | oxidative stress resistance | autofluorescence (age pigment / lipofuscin) | quantity of apoptotic cells | ROS level | mean lifespan | ||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
0.5 mg/ml | 48 h; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | up | yes | A2; stressor: 35°C | none | no | A2; stressor: 10 mM H2O2 | Zhou, Y., Xu, Q., Zhou, X., Song, S., & Zhu, B. (2018). Stress resistance and lifespan extension of Caenorhabditis elegans enhanced by peptides from mussel (Mytilus edulis) protein hydrolyzate. Food & function, 9(6), 3313-3320. | no | ||||||||||||||||||||||||||||||
2 mg/ml | 48 h; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | up | yes | A2; stressor: 35°C | up | yes | A2; stressor: 10 mM H2O2 | Zhou, Y., Xu, Q., Zhou, X., Song, S., & Zhu, B. (2018). Stress resistance and lifespan extension of Caenorhabditis elegans enhanced by peptides from mussel (Mytilus edulis) protein hydrolyzate. Food & function, 9(6), 3313-3320. | no | ||||||||||||||||||||||||||||||
4 mg/ml | 48 h; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | up | yes | A3, A8 | up | yes | A8 | up | yes | A2; stressor: 35°C | up | yes | A2; stressor: 10 mM H2O2 | down | yes | A8; blue fluorescence | down | yes | A8 | down | yes | A8 | up | 30 | yes | A2; upregulation of daf-16; downregulation of daf-2 | Zhou, Y., Xu, Q., Zhou, X., Song, S., & Zhu, B. (2018). Stress resistance and lifespan extension of Caenorhabditis elegans enhanced by peptides from mussel (Mytilus edulis) protein hydrolyzate. Food & function, 9(6), 3313-3320. | no |