Compound ID 251   (prev - next)

Name: NG-094 (edit)

18 entries:
TreatmentNG-094physical functionreproductive functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLlocomotion on solid medianumber of offspringspeed of larval developmentonset of egg layingquantity of polyQ aggregatesactivity / quantity / expression of HSPsactivity / quantity / expression of HSPsactivity / quantity / expression of HSPsmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
0.25 mMwhole life; start: unknownOP50NGM agarFUDRAM134 {rmIs126 [unc-54p::Q0::YFP]}22°Cnonen.d.A1Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
0.5 mMwhole life; start: unknownOP50NGM agarFUDRAM134 {rmIs126 [unc-54p::Q0::YFP]}22°Cnonen.d.A1Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
0.75 mMwhole life; start: unknownOP50NGM agarFUDRAM134 {rmIs126 [unc-54p::Q0::YFP]}22°Cdownn.d.A1Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
1.0 mMwhole life; start: unknownOP50NGM agarFUDRAM134 {rmIs126 [unc-54p::Q0::YFP]}22°CupyesA3; decreased motility (not significant) at A1upn.d.A1; western blot analysis; up-regulation after 29°C heat shock for 3h; unchanged without heat shock; RT-PCR didn't show any changes for hsp-16.2 as well as for hsp-40, hsp-70, hsp-16.11, and hsp-90nonen.d.A1; western blot analysis; unchanged regulation after 29°C heat shock for 3h as well as without heat shock; RT-PCR didn't show any changes for hsp-40 as well as for hsp-16.2, hsp-70, hsp-16.11, and hsp-90Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
1.25 mMwhole life; start: unknownOP50NGM agarFUDRAM134 {rmIs126 [unc-54p::Q0::YFP]}22°Cdownn.d.A1Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
0.25 mMwhole life; start: unknownOP50NGM agarFUDRAM140 {rmIs132 [unc-54p::Q35::YFP]}22°Cnonen.d.A1Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
0.5 mMwhole life; start: unknownOP50NGM agarFUDRAM140 {rmIs132 [unc-54p::Q35::YFP]}22°Cupn.d.A1Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
0.75 mMwhole life; start: unknownOP50NGM agarFUDRAM140 {rmIs132 [unc-54p::Q35::YFP]}22°Cupn.d.A1Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
1.0 mMwhole life; start: unknownOP50NGM agarFUDRAM140 {rmIs132 [unc-54p::Q35::YFP]}22°CupyesA1; also significantly increased at A3down-20.00yesvariablen.d.A1; western blot analysis; up-regulation after 29°C heat shock for 3h; down-regulation without heat shock; RT-PCR didn't show any changes for hsp-16.2 as well as for hsp-40, hsp-70, hsp-16.11, and hsp-90downn.d.A1; western blot analysis; slightly down-regulation after 29°C heat shock for 3h as well as without heat shock; RT-PCR didn't show changes for hsp-40 as well as for hsp-16.2, hsp-70, hsp-16.11, and hsp-90HSF-1Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
1.25 mMwhole life; start: unknownOP50NGM agarFUDRAM140 {rmIs132 [unc-54p::Q35::YFP]}22°Cupn.d.A1Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
1.0 mMwhole life; start: unknownOP50NGM agarAM134 {rmIs126 [unc-54p::Q0::YFP]}22°Cdown-10.00yesdownn.d.delayedn.d.up3.47nonone0noHaldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
1.0 mMwhole life; start: unknownOP50NGM agarAM140 {rmIs132 [unc-54p::Q35::YFP]}22°Cdown-20.00yesdownn.d.delayedn.d.up7.04noup17.61yesHaldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
1.0 mMwhole life; start: unknownOP50NGM agarFUDRBC10060 {dpy-5(e907); sEx884 [rCesC12C8.1::GFP + pCeh361]}22°Cupn.d.A1; western blot analysis; after 29°C heat shock for 3hHaldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
1.0 mMwhole life; start: A1HT115 (DE3) with RNAi-vector against hsf-1NGM agarFUDRAM140 {rmIs132 [unc-54p::Q35::YFP]}20°CnonenoA3Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.
1.0 mMwhole life; start: unknownHT115 (DE3) with RNAi-vector against daf-16NGM agarFUDRAM140 {rmIs132 [unc-54p::Q35::YFP]}22°CupyesA1Haldimann P, Muriset M, Vígh L, Goloubinoff P. Haldimann P, Muriset M, Vígh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286, 18784-18794.