Treatment | Nymphaea hybrid root extract | physical function | reproductive function | physiological function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | | ChEMBL | | | | | locomotion in liquid media | | | | number of offspring | | | | speed of larval development | | | | heat stress resistance | | | | oxidative stress resistance | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
0.2 mg/ml | whole life; start: L4 | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | up | | yes | | | | | | Zhuang, Z., Lv, T., Li, M., Zhang, Y., Xue, T., Yang, L., ... & Zhang, W. (2014). The lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans. Plant foods for human nutrition, 69(4), 304-309. | |
1 mg/ml | whole life; start: L4 | OP50 | NGM agar | | N2 (wild type) | 20°C | up | | yes | A4 - A20; body bends and head thrashes | down | | yes | | none | | no | hatching rate and survival of larvae | up | | yes | A2; stressor: 35°C; endpoint: mean lifespan | up | | yes | A2; stressor: 0.1 mg/ml of paraquat; endpoint: mean lifespan | up | | yes | | | | | insulin/IGF signaling pathway | Zhuang, Z., Lv, T., Li, M., Zhang, Y., Xue, T., Yang, L., ... & Zhang, W. (2014). The lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans. Plant foods for human nutrition, 69(4), 304-309. | |
5 mg/ml | whole life; start: L4 | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | up | | no | | | | | | Zhuang, Z., Lv, T., Li, M., Zhang, Y., Xue, T., Yang, L., ... & Zhang, W. (2014). The lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans. Plant foods for human nutrition, 69(4), 304-309. | |
1 mg/ml | whole life; start: L4 | OP50, heat-inactivated | NGM agar | | N2 (wild type) | 23°C | | | | | | | | | | | | | | | | | | | | | up | | yes | | | | | | Zhuang, Z., Lv, T., Li, M., Zhang, Y., Xue, T., Yang, L., ... & Zhang, W. (2014). The lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans. Plant foods for human nutrition, 69(4), 304-309. | |
1 mg/ml | whole life; start: L4 | OP50 | NGM agar | | CF1038 [daf-16(mu86)] | 23°C | | | | | | | | | | | | | | | | | | | | | none | | no | | | | | | Zhuang, Z., Lv, T., Li, M., Zhang, Y., Xue, T., Yang, L., ... & Zhang, W. (2014). The lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans. Plant foods for human nutrition, 69(4), 304-309. | |