Compound ID 259   (prev - next)

Name: O-acetyl glucomannan (edit)

6 entries:
TreatmentO-acetyl glucomannanphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLpharyngeal pumpingquantity of early reproductionquantity of late reproductionoxidative stress resistanceheat stress resistanceROS levelactivity / quantity / expression of SODsactivity / quantity / expression of CTLsautofluorescence (age pigment / lipofuscin)MDA levelmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperaturechange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)notes
0.25 mg/mlwhole life; start: L4OP50NGM agarN2 (wild type)20°CnonenoA5, A10, A15nonenononenoup25yesA2; stressor: 40 mM H2O2; endpoint: mean survivalup40yesA2; stressor: 35°C; endpoint: mean survivaldown-35.95yesA10; measured via H2DCF-DAup1.62noA10up8.46noA10down-35.91yesA10; blue fluorescencedown-21.93noA10up13.33noHui H, Xin A, Cui H, Jin H, Yang X, Liu H, Qin B (2020) Anti-aging effects on Caenorhabditis elegans of a polysaccharide, O-acetyl glucomannan, from roots of Lilium davidii var. unicolor Cotton. Int J Biol Macromol 155, 846-852. no
1 mg/mlwhole life; start: L4OP50NGM agarN2 (wild type)20°CnonenoA5, A10, A15upyesnonenoup26yesA2; stressor: 40 mM H2O2; endpoint: mean survivalup60yesA2; stressor: 35°C; endpoint: mean survivaldown-50.3yesA10; measured via H2DCF-DAup29.51yesA10up33.19noA10down-50.3yesA10; blue fluorescencedown-48.26yesA10up20noHui H, Xin A, Cui H, Jin H, Yang X, Liu H, Qin B (2020) Anti-aging effects on Caenorhabditis elegans of a polysaccharide, O-acetyl glucomannan, from roots of Lilium davidii var. unicolor Cotton. Int J Biol Macromol 155, 846-852. no
4 mg/mlwhole life; start: L4OP50NGM agarN2 (wild type)20°Cup26.42noA5; only slightly increased at A10 & A15upyesnonenoup50yesA2; stressor: 40 mM H2O2; endpoint: mean survivalup61yesA2; stressor: 35°C; endpoint: mean survivaldown-69.75yesA10; measured via H2DCF-DAup39.03yesA10up41.89yesA10down-69.79yesA10; blue fluorescencedown-52.63yesA10up40noHui H, Xin A, Cui H, Jin H, Yang X, Liu H, Qin B (2020) Anti-aging effects on Caenorhabditis elegans of a polysaccharide, O-acetyl glucomannan, from roots of Lilium davidii var. unicolor Cotton. Int J Biol Macromol 155, 846-852. no