Treatment | O-acetyl glucomannan | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||||||||||||
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CID (PubChem) | ChEMBL | pharyngeal pumping | quantity of early reproduction | quantity of late reproduction | oxidative stress resistance | heat stress resistance | ROS level | activity / quantity / expression of SODs | activity / quantity / expression of CTLs | autofluorescence (age pigment / lipofuscin) | MDA level | mean lifespan | ||||||||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | ||||||
0.25 mg/ml | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | A5, A10, A15 | none | no | none | no | up | 25 | yes | A2; stressor: 40 mM H2O2; endpoint: mean survival | up | 40 | yes | A2; stressor: 35°C; endpoint: mean survival | down | -35.95 | yes | A10; measured via H2DCF-DA | up | 1.62 | no | A10 | up | 8.46 | no | A10 | down | -35.91 | yes | A10; blue fluorescence | down | -21.93 | no | A10 | up | 13.33 | no | Hui H, Xin A, Cui H, Jin H, Yang X, Liu H, Qin B (2020) Anti-aging effects on Caenorhabditis elegans of a polysaccharide, O-acetyl glucomannan, from roots of Lilium davidii var. unicolor Cotton. Int J Biol Macromol 155, 846-852. | no | |||||||||||
1 mg/ml | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | A5, A10, A15 | up | yes | none | no | up | 26 | yes | A2; stressor: 40 mM H2O2; endpoint: mean survival | up | 60 | yes | A2; stressor: 35°C; endpoint: mean survival | down | -50.3 | yes | A10; measured via H2DCF-DA | up | 29.51 | yes | A10 | up | 33.19 | no | A10 | down | -50.3 | yes | A10; blue fluorescence | down | -48.26 | yes | A10 | up | 20 | no | Hui H, Xin A, Cui H, Jin H, Yang X, Liu H, Qin B (2020) Anti-aging effects on Caenorhabditis elegans of a polysaccharide, O-acetyl glucomannan, from roots of Lilium davidii var. unicolor Cotton. Int J Biol Macromol 155, 846-852. | no | |||||||||||
4 mg/ml | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | up | 26.42 | no | A5; only slightly increased at A10 & A15 | up | yes | none | no | up | 50 | yes | A2; stressor: 40 mM H2O2; endpoint: mean survival | up | 61 | yes | A2; stressor: 35°C; endpoint: mean survival | down | -69.75 | yes | A10; measured via H2DCF-DA | up | 39.03 | yes | A10 | up | 41.89 | yes | A10 | down | -69.79 | yes | A10; blue fluorescence | down | -52.63 | yes | A10 | up | 40 | no | Hui H, Xin A, Cui H, Jin H, Yang X, Liu H, Qin B (2020) Anti-aging effects on Caenorhabditis elegans of a polysaccharide, O-acetyl glucomannan, from roots of Lilium davidii var. unicolor Cotton. Int J Biol Macromol 155, 846-852. | no |