Compound ID 263 (prev - next)

Name: Oleanolic acid (10494) (edit)

11 entries:

Treatment	Oleanolic acid						physical function				physiological function								healthspan biomarkers								lifespan				Transcriptome	Target	Reference
CID (PubChem)	10494	ChEMBL					pharyngeal pumping				heat stress resistance				oxidative stress resistance				ROS level				translocation of DAF-16 to nucleus				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C									up	9.68	yes	A3; stressor: 5 mM paraquat; endpoint: survival									up	3.07	no				Zhang J, Lu L, Zhou L (2015) Oleanolic acid activates daf-16 to increase lifespan in Caenorhabditis elegans. Biochem Biophys Res Commun 468, 843-849.
200 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C									up	15.08	yes	A3; stressor: 5 mM paraquat; endpoint: survival									up	11.18	yes				Zhang J, Lu L, Zhou L (2015) Oleanolic acid activates daf-16 to increase lifespan in Caenorhabditis elegans. Biochem Biophys Res Commun 468, 843-849.
300 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C	none		no	A3, A6, and A10	up		n.d.	A3; stressor: 36°C; endpoint: survival	up	19.50	yes	A3; stressor: 5 mM paraquat; endpoint: survival	down		yes	A3; exposed to 37°C during measurement; measured via H2DCF-DA					up	16.63	yes		up-regulation of daf-16, sod-3, hsp-16.2, and ctl-1	daf-16, sod-3, hsp-16.2, and ctl-1	Zhang J, Lu L, Zhou L (2015) Oleanolic acid activates daf-16 to increase lifespan in Caenorhabditis elegans. Biochem Biophys Res Commun 468, 843-849.
600 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C									up	15.21	yes	A3; stressor: 5 mM paraquat; endpoint: survival									up	2.70	no				Zhang J, Lu L, Zhou L (2015) Oleanolic acid activates daf-16 to increase lifespan in Caenorhabditis elegans. Biochem Biophys Res Commun 468, 843-849.
300 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	GR1307 [daf-16(mgDf50)]	20°C																					down	-0.41	no				Zhang J, Lu L, Zhou L (2015) Oleanolic acid activates daf-16 to increase lifespan in Caenorhabditis elegans. Biochem Biophys Res Commun 468, 843-849.
300 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	20°C																					up		yes				Zhang J, Lu L, Zhou L (2015) Oleanolic acid activates daf-16 to increase lifespan in Caenorhabditis elegans. Biochem Biophys Res Commun 468, 843-849.
300 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	DA1116 [eat-2(ad1116)]	20°C																					up		yes				Zhang J, Lu L, Zhou L (2015) Oleanolic acid activates daf-16 to increase lifespan in Caenorhabditis elegans. Biochem Biophys Res Commun 468, 843-849.
300 µM	2 h; start: A1	OP50, heat-inactivated	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																	up	435.38	yes	A1							Zhang J, Lu L, Zhou L (2015) Oleanolic acid activates daf-16 to increase lifespan in Caenorhabditis elegans. Biochem Biophys Res Commun 468, 843-849.