Compound ID 267 (prev - next)

Name: Otophylloside B (10079485) (edit)

20 entries:

Treatment	Otophylloside B						cognitive function				physical function								physiological function				healthspan biomarkers								lifespan								Transcriptome	Target	Reference
CID (PubChem)	10079485	ChEMBL					chemotaxis				locomotion on solid media				fast body movement span				heat stress resistance				quantity of β-Amyloid				translocation of DAF-16 to nucleus				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
5 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																									up	4.30	yes								Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
20 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																									up	6.60	yes								Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C									up	9.53	yes		up	42.77	yes	A 5; stressor: 35°C; endpoint: survival									up	11.40	yes						up-regulation of sod-3	DAF-16, DAf-2, SIR-21, and CLK-1	Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
200 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																									up	6.30	yes								Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
500 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																									up	2.20	no								Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	DA1116 [eat-2(ad1116)]	20°C																									up	14.65	yes								Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	20°C																									none		no								Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	CB4876 [clk-1(e2519)]	20°C																									none		no								Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	CB1370 [daf-2(e1370)]	20°C																									none		no								Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																					up		n.d.	A2											Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	CF1038 [daf-16(mu86)]	20°C																									none		no								Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]	20°C																									up	12.81	yes		up		n.d.				Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR (2015) The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect 5, 177-183.
50 µM	whole life; start: L3	OP50, heat-inactivated	NGM agar		CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C					up	160.76	yes	young adults; pre-exposed to 25°C; endpoint: ratio of non-paralyzed and paralyzed worms 36 h after temperature shift; similar results 30 h after shift; no significant change 24 h after shift																											Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR (2017) Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect 7, 207-214.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}	16°C																									up	5.25	yes								Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR (2017) Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect 7, 207-214.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar		CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}	16°C					up	21.40	yes	young adults; endpoint: ratio of non-paralyzed and paralyzed worms					up	16.77	yes	A1; stressor: 35°C; endpoint: survival; similar change after recovery period	down		yes	A3 and A5; measured via fluorescence and qRT-PCR													up-regulation of sod-3, hsf-1, hsp-12.6, hsp-16.2, and hsp-70	hsf-1, hsp-12.6, hsp-16.2, hsp-70, sod-3, and daf-16	Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR (2017) Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect 7, 207-214.
50 µM	whole life; start: L1	OP50, heat-inactivated	NGM agar		CL2122 {dvIs15 [(pPD30.38) unc-54(vector) + (pCL26) mtl-2::GFP]}	16°C	none		no	attractant: benzaldehyde																															Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR (2017) Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect 7, 207-214.
50 µM	whole life; start: L1	OP50, heat-inactivated	NGM agar		CL2355{smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]}	16°C	up	32.00	yes	attractant: benzaldehyde																															Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR (2017) Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect 7, 207-214.