Compound ID 270   (prev - next)

Name: PBT2 (10016012) (edit)

4 entries:
TreatmentPBT2physical functionTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)10016012ChEMBLlocomotion on solid media
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notes
10 µg/mlwhole life; start: L4OP50NGM agarAmpicillinAM140 {rmIs132 [unc-54p::Q35::YFP]}25 °CupyesA7-A10; Paralysis assay; no significant changes at A5 & A6Cherny, R. A., Ayton, S., Finkelstein, D. I., Bush, A. I., McColl, G., & Massa, S. M. (2012). PBT2 reduces toxicity in a C. elegans model of polyQ aggregation and extends lifespan, reduces striatal atrophy and improves motor performance in the R6/2 mouse model of Huntington's disease. Journal of Huntington's disease, 1(2), 211-219.