Treatment | Panax notoginseng branch roots polysaccharides | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||||||||||||||||
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CID (PubChem) | ChEMBL | food consumption | heat stress resistance | activity / quantity / expression of SODs | activity / quantity / expression of CTLs | MDA level | mean lifespan | maximum lifespan | ||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
0.1 mg/mL | whole life; start: A1 | OP50 | NGM agar | N2 (wild type) | 20°C | down | n.d. | up | n.d. | A3; stressor: 35°C; endpoint: survival | up | 19.70 | yes | A3; activity of SOD; pre-exposed to 35°C for 5 h | up | 22.40 | yes | A3; activity of catalase; pre-exposed to 35°C for 5 h | down | -17.10 | yes | A3; pre-exposed to 35°C for 5 h | up | 10.50 | n.d. | up | n.d. | SOD and catalase | Feng S, Cheng H, Xu Z, Shen S, Yuan M, Liu J, Ding C (2015) Thermal stress resistance and aging effects of Panax notoginseng polysaccharides on Caenorhabditis elegans. Int J Biol Macromol 81, 188-194. | |||||||||||
0.5 mg/mL | whole life; start: A1 | OP50 | NGM agar | N2 (wild type) | 20°C | down | n.d. | Feng S, Cheng H, Xu Z, Shen S, Yuan M, Liu J, Ding C (2015) Thermal stress resistance and aging effects of Panax notoginseng polysaccharides on Caenorhabditis elegans. Int J Biol Macromol 81, 188-194. | ||||||||||||||||||||||||||||||||
1 mg/mL | whole life; start: A1 | OP50 | NGM agar | N2 (wild type) | 20°C | down | n.d. | Feng S, Cheng H, Xu Z, Shen S, Yuan M, Liu J, Ding C (2015) Thermal stress resistance and aging effects of Panax notoginseng polysaccharides on Caenorhabditis elegans. Int J Biol Macromol 81, 188-194. | ||||||||||||||||||||||||||||||||
1.5 mg/mL | whole life; start: A1 | OP50 | NGM agar | N2 (wild type) | 20°C | down | n.d. | Feng S, Cheng H, Xu Z, Shen S, Yuan M, Liu J, Ding C (2015) Thermal stress resistance and aging effects of Panax notoginseng polysaccharides on Caenorhabditis elegans. Int J Biol Macromol 81, 188-194. | ||||||||||||||||||||||||||||||||
2 mg/mL | whole life; start: A1 | OP50 | NGM agar | N2 (wild type) | 20°C | down | n.d. | Feng S, Cheng H, Xu Z, Shen S, Yuan M, Liu J, Ding C (2015) Thermal stress resistance and aging effects of Panax notoginseng polysaccharides on Caenorhabditis elegans. Int J Biol Macromol 81, 188-194. |