10 nM | whole life; start: egg stage | OP50 | NGM agar | | CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]} | 20°C | none | | | paralysis assay with daily measurements of Alzheimer disease model | | | | | | | | | Keowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365. | |
100 nM | whole life; start: egg stage | OP50 | NGM agar | | CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]} | 20°C | up | | yes | paralysis assay with daily measurements of Alzheimer disease model | down | | n.d. | A1 | | | | | Keowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365. | |
1 µM | whole life; start: egg stage | OP50 | NGM agar | | CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]} | 20°C | none | | | paralysis assay with daily measurements of Alzheimer disease model | | | | | | | | | Keowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365. | |
10 µM | whole life; start: egg stage | OP50 | NGM agar | | CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]} | 20°C | none | | | paralysis assay with daily measurements of Alzheimer disease model | | | | | | | | | Keowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365. | |
100 µM | whole life; start: egg stage | OP50 | NGM agar | | CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]} | 20°C | none | | | paralysis assay with daily measurements of Alzheimer disease model | | | | | | | | | Keowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365. | |