| Treatment | Proanthocyanidin | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 108065 | ChEMBL | heat stress resistance | oxidative stress resistance | concentration of N(6)-Carboxymethyllysine (CML) | ROS level | mean lifespan | |||||||||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 67 µg/mL | whole life; start: unknown | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | yes | A5; stressor: 35°C for 16h; endpoint: survival | up | variable | A5; stressor: 40 µM paraquat; endpoint: survival | down | yes | A5; measured via ELISA | down | yes | A2; measured via H2DCF-DA | up | yes | Mekheimer RA, Sayed AA, Ahmed EA, Sadek KU (2015) Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects. Arch Pharm (Weinheim) 348, 650-665. | |||||||||||