Compound ID 285   (prev - next)

Name: protocatechuic acid (72) (edit)

9 entries:
Treatmentprotocatechuic acidphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)72ChEMBLpharyngeal pumpinglocomotion on solid medianumber of offspringquantity of early reproductionheat stress resistanceoxidative stress resistanceosmotic stress resistanceATP levelROS levellactate levelpyruvate levelmitochondrial content/qualityactivity / quantity / expression of SODsactivity / quantity / expression of CTLsmitochondrial membrane potentialmedian lifespanmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
100 µMwhole life; start: egg stageOP50NGM agarN2 (wild type)20°CdownyesA4; no significant changes at A8upnoA8; unchanged movement at A4downyesdownn.d.upyesA4; Stressor: 36°C; endpoint: mean lifespanupyesA7; Stressor: 60 mM paraquat; endpoint: mean lifespanupyesA3; Stressor: 500 mM NaCl for 12 hdownyesA4; measurement via H2-DCF-DA; pre-incubation: 30 mM paraquat for 3 h; significant differences after 60, 90, and 120 min after paraquat treatmentnonenoA5; measurement of enzyme activity with the aid of xanthineupnoA5; measurement of enzyme activity with the aid of H2O2upyesup25.00n.d.Kim YS, Seo HW, Lee MH, Kim DK, Jeon H, Cha DS (2014) Protocatechuic acid extends lifespan and increases stress resistance in Caenorhabditis elegans. Arch Pharm Res 37, 245-252.
200 µMwhole life; start: egg stageOP50NGM agarN2 (wild type)20°CdownyesA4; no significant changes at A8upyesA8; unchanged movement at A4downyesdownn.d.upyesA4; Stressor: 36°C; endpoint: mean lifespanupyesA7; Stressor: 60 mM paraquat; endpoint: mean lifespanupyesA3; Stressor: 500 mM NaCl for 12 hdownyesA4; measurement via H2-DCF-DA; pre-incubation: 30 mM paraquat for 3 h; significant differences after 60, 90, and 120 min after paraquat treatmentupyesA5; measurement of enzyme activity with the aid of xanthineupyesA5; measurement of enzyme activity with the aid of H2O2up38.95yesup40.00n.d.Kim YS, Seo HW, Lee MH, Kim DK, Jeon H, Cha DS (2014) Protocatechuic acid extends lifespan and increases stress resistance in Caenorhabditis elegans. Arch Pharm Res 37, 245-252.
100 µMwhole life; start: A8OP50NGM agarN2 (wild type)20°CnonenoA12upyesKim YS, Seo HW, Lee MH, Kim DK, Jeon H, Cha DS (2014) Protocatechuic acid extends lifespan and increases stress resistance in Caenorhabditis elegans. Arch Pharm Res 37, 245-252.
200 µMwhole life; start: A8OP50NGM agarN2 (wild type)20°CnonenoA12upyesKim YS, Seo HW, Lee MH, Kim DK, Jeon H, Cha DS (2014) Protocatechuic acid extends lifespan and increases stress resistance in Caenorhabditis elegans. Arch Pharm Res 37, 245-252.
780 µMwhole life; start: A1OP50NGM agarN2 (wild type)20°Cup20yesDilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria. Nutrients 11, 1886. no
780 µMwhole life; start: A1OP50liquid NGMN2 (wild type)20°Cup14.29yesA3, stressor: 37°C; endpoint: median lifespanup21yesA3downnoA3nonenoA3upyesA3; determined by the activities of mitochondrial respiratory systemupyesA3; determined with the fluorescent dye Rhodamine 123Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria. Nutrients 11, 1886. no