Compound ID 286 (prev - next)

Name: Psammaplysene A (11434210) (edit)

8 entries:

Treatment	Psammaplysene A						cognitive function				healthspan biomarkers				Target	Reference
CID (PubChem)	11434210	ChEMBL					neuronal survival / integrity				translocation of DAF-16 to nucleus
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
0.2 nM	whole life; start: L1	N/A	NGM agar		ZB1102 {glt-3(bz34); nuIs5 [glr-1::GFP + glr-1::G(alpha)s(Q227L) + lin-15(+)]}	N/A	up		yes	L3						Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG (2009) FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci 29, 8236-8247. doi: 10.1523/JNEUROSCI.1805-09.2009.
2.0 nM	whole life; start: L1	N/A	NGM agar		ZB1102 {glt-3(bz34); nuIs5 [glr-1::GFP + glr-1::G(alpha)s(Q227L) + lin-15(+)]}	N/A	up		yes	L3						Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG (2009) FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci 29, 8236-8247. doi: 10.1523/JNEUROSCI.1805-09.2009.
20 nM	whole life; start: L1	N/A	NGM agar		ZB1102 {glt-3(bz34); nuIs5 [glr-1::GFP + glr-1::G(alpha)s(Q227L) + lin-15(+)]}	N/A	up	47.62	yes	L3; percentual change of 26.47 in L2; no change in L1 and L4						Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG (2009) FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci 29, 8236-8247. doi: 10.1523/JNEUROSCI.1805-09.2009.
20 nM	whole life; start: L1	N/A	NGM agar		KP742 {nuIs5 [glr-1::gfp; glr-1::Gs(Q227L); lin-15 (+)]}	N/A	up		no	L3					daf-16	Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG (2009) FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci 29, 8236-8247. doi: 10.1523/JNEUROSCI.1805-09.2009.
10 nM	whole life; start: L1	N/A	NGM agar		ZB2283 {Pmyo-3:daf-16::gfp}	N/A					up	135.62	yes	L3		Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG (2009) FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci 29, 8236-8247. doi: 10.1523/JNEUROSCI.1805-09.2009.