| Treatment | Qibao meiran dan (TCM formula) | reproductive function | physiological function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | number of offspring | heat stress resistance | oxidative stress resistance | median lifespan | mean lifespan | ||||||||||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 2 g/l | whole life; start: L4 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | n.d. | down | -14.7 | n.d. | down | -4.2 | no | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||||||
| 10.1 g/l | whole life; start: L4 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | n.d. | up | 10.40 | n.d. | up | 15.80 | yes | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||||||
| 10.1 g/l | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | n.d. | down | -5.00 | n.d. | up | 0.70 | no | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||||||
| 10.1 g/l | whole life; start: L1 | OP50 | NGM agar | FUDR | N2 (wild type) | n.d. | down | no | down | -97.47 | yes | A1; stressor: 35°C for 22.5 h; endpoint: survival | up | 0.47 | no | L1; stressor: 10 mM paraquat; endpoint: survival after 3.5 days | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||
| 10.1 g/l | whole life; start: L1 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | n.d. | none | no | down | -53.69 | yes | A1; stressor: 35°C for 28 h; endpoint: survival | up | 173.93 | yes | L1; stressor: 10 mM paraquat; endpoint: survival after 3.5 days | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||