Compound ID 290   (prev - next)

Name: Quercetin (5280343) (edit)

18 entries:
TreatmentQuercetinphysical functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)5280343ChEMBLCHEMBL50locomotion on solid mediaheat stress resistanceoxidative stress resistanceautofluorescence (age pigment / lipofuscin)ROS levelquantity of β-Amyloidactivity / quantity / expression of SODsactivity / quantity / expression of GSTstranslocation of DAF-16 to nucleusmedian lifespanmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
50 µg/mlwhole life; start: A1OP50NGM agarN2 (wild type)22 °Cdown-8.33nosignificance was determined for mean lifespan (log rank test)down-16.67Wu Z, Smith JV, Paramasivam V, Butko P, Khan I, Cypser JR, Luo Y (2002) Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans. Cell Mol Biol (Noisy-le-grand) 48, 725-731.
100 µMwhole life; start: L1OP50-1liquid NGMStreptomycinN2 (wild type)20°Cup19.62yesA1; Stressor: 150 µM Jugloneup19.05yesup15.17yesup14.97n.d.DAF-16Kampkötter A, Timpel C, Zurawski RF, Ruhl S, Chovolou Y, Proksch P, Wätjen W (2008) Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp Biochem Physiol B Biochem Mol Biol 149, 314-323.
100 µMwhole life; start: L1OP50-1liquid NGMStreptomycinCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°Cdown-15.00yesA1; SOD-3-promoter activity measured by fluorescenceKampkötter A, Timpel C, Zurawski RF, Ruhl S, Chovolou Y, Proksch P, Wätjen W (2008) Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp Biochem Physiol B Biochem Mol Biol 149, 314-323.
100 µMwhole life; start: L1OP50-1liquid NGMStreptomycinTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°CupyesA1Kampkötter A, Timpel C, Zurawski RF, Ruhl S, Chovolou Y, Proksch P, Wätjen W (2008) Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp Biochem Physiol B Biochem Mol Biol 149, 314-323.
50 µg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup14.2yesA5; Stressor: 35°C; endpoint: mean lifespan; median lifespan is also significantly increasedup65.8yesA2; Stressor: 0.5 mM H2O2 for 8 hUpadhyay A, Chompoo J, Taira N, Fukuta M, Tawata S (2013) Significant longevity-extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans. Biosci Biotechnol Biochem 77, 217-223.
50 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinN2 (wild type)20°Cup8.30noA2; stressor: 37°C; endpoint: mean lifespan; similar change in median lifespandownyesA2; exposed to 37°C during measurement; measured via H2DCF-DABüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinN2 (wild type)20°Cup14.11yesA2; stressor: 37°C; endpoint: mean lifespan; similar change in median lifespandown-27.85yesA7; blue fluorescencedownyesA2; exposed to 37°C during measurement; measured via H2DCF-DABüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CdownyesA5; sod-3 expression; pre-exposed to juglone; unchanged without juglone exposure; measured via fluorescenceBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CdownyesA5; gst-4 expression; pre-exposed to juglone; no significant change without pre-exposure; measured via fluorescenceBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinN2 (wild type)25°Cup27.78n.d.up18.92yesBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinCF1038 [daf-16(mu86)]25°Cup27.27n.d.up14.39yesBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
200 µg/mLwhole life; start: egg stageOP50NGM agarGentamycinCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}20°CupnoL3; temperature shift to 23°C prior analysing beta-amyloid induced paralysisSangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
200 µg/mLwhole life; start: egg stageOP50NGM agarGentamycinCL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}20°CdownnoA4 & A8Sangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
200 µg/mLwhole life; start: egg stageOP50NGM agarGentamycinN2 (wild type)20°CupyesL4; stressor: 300 µM juglone; endpoint: survivalSangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
100 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup8,8yesA1; stressor: 37°C; endpoint: survivalZhou, J. B., Zheng, Y. L., Zeng, Y. X., Wang, J. W., Pei, Z., & Pang, J. Y. (2018). Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans. European journal of medicinal chemistry, 148, 63-72.