Compound ID 292 (prev - next)

Name: Rapamycin (5284616) (edit)

8 entries:

Treatment	Rapamycin						physical function								healthspan biomarkers				lifespan				Transcriptome	Target	Reference
CID (PubChem)	5284616	ChEMBL	CHEMBL413				pharyngeal pumping				locomotion on solid media				level of autophagy				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
1 µg/ml	whole life; start: unknown	OP50	NGM agar		N2 (wild type)	20°C									up			Measured with a DsRed::LGG-1 transgene reporter gene product						Autophagy pathway	Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, Michaud M, Madeo F, Tavernarakis N, Kroemer G (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1:e10,
1 µg/ml	whole life; start: unknown	OP50	NGM agar		VC199 [sir-2.1(ok434)]	20°C									up			Measured with a DsRed::LGG-1 transgene reporter gene product							Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, Michaud M, Madeo F, Tavernarakis N, Kroemer G (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1:e10,
10 µM	whole life; start: L4	OP50, ethanol- and UV-inactivated	NGM agar	FUDR	N2 (wild type)	20°C	up	79.05	yes	A10; unchanged at A1, A5, and A15	down		no	A5; unchanged at A1; variable at A10 and A15; endpoint: number of body bends					up	18.93	yes		whole genome array; supplemental table available		Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.
10 µM	whole life; start: L4	OP50, ethanol- and UV-inactivated	NGM agar	FUDR	DA465[eat-2(ad465)]	20°C													up	4.63	no		whole genome array; supplemental table available		Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.
10 µM	whole life; start: L4	OP50, ethanol- and UV-inactivated	NGM agar	FUDR	GR1307 [daf-16(mgDf50)]	20°C													up	21.70	yes				Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.