Treatment | Rechtsregulat® | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | ChEMBL | heat stress resistance | ATP level | lactate level | pyruvate level | mitochondrial content/quality | mitochondrial membrane potential | median lifespan | ||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | ||||||
5% | whole life; start: A1 | OP50 | NGM agar | N2 (wild type) | 20°C | Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria. Nutrients 11, 1886. | no | |||||||||||||||||||||||||||||||||
10% | whole life; start: A1 | OP50 | NGM agar | N2 (wild type) | 20°C | up | 10 | yes | A3; upregulation of daf-16, skn-1 | Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria. Nutrients 11, 1886. | no | |||||||||||||||||||||||||||||
5% | whole life; start: A1 | OP50 | liquid NGM | N2 (wild type) | 20°C | none | no | A3, stressor: 37°C; endpoint: median lifespan | Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria. Nutrients 11, 1886. | no | ||||||||||||||||||||||||||||||
10% | whole life; start: A1 | OP50 | liquid NGM | N2 (wild type) | 20°C | up | 9.5 | A3, stressor: 37°C; endpoint: median lifespan | down | no | A3 | up | 143 | yes | A3 | up | no | A3 | up | yes | A3; determined by the activities of mitochondrial respiratory system | down | no | A3; determined with the fluorescent dye Rhodamine 123 | Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria. Nutrients 11, 1886. | no |