Compound ID 294   (prev - next)

Name: Red mold dioscorea (ethanol extract) (edit)

11 entries:
TreatmentRed mold dioscorea (ethanol extract)physiological functionhealthspan biomarkersTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLoxidative stress resistanceoxidative stress resistanceoxidative stress resistanceROS levelactivity / quantity / expression of SODstranslocation of DAF-16 to nucleus
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
1 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CupyesA1; stressor: 250 µM juglone for 3.5 h; no change by the use of other juglone concentrations; endpoint: survivaldownyesA1; measured via H2DCF-DAShi YC, Yu CW, Liao VH, Pan TM (2012) Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. PLoS One 7, e39515.
10 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CupyesA1; stressor: 250 µM juglone for 3.5 h; no change by the use of other juglone concentrations; endpoint: survivalupyesA1; stressor: 1 mM H2O2 for 4.5 h; endpoint: survivalupyesA1; stressor: 150 mM paraquat for 12 h; endpoint: survivaldownyesA1; measured via H2DCF-DAup-regulation of sod-3DAF-16, SOD-3Shi YC, Yu CW, Liao VH, Pan TM (2012) Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. PLoS One 7, e39515.
50 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CupyesA1; stressor: 250 µM juglone for 3.5 h; no change by the use of other juglone concentrations; endpoint: survivaldownyesA1; measured via H2DCF-DAShi YC, Yu CW, Liao VH, Pan TM (2012) Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. PLoS One 7, e39515.
10 µg/mlwhole life; start: L1OP50liquid S-mediumGR1307 [daf-16(mgDf50)]20°CnonenoA1; stressor: 250 µM juglone for 3.5 h; endpoint: survivalShi YC, Yu CW, Liao VH, Pan TM (2012) Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. PLoS One 7, e39515.
10 µg/mlwhole life; start: L1OP50liquid S-mediumCF1038 [daf-16(mu86)]20°CnonenoA1; stressor: 250 µM juglone for 3.5 h; endpoint: survivalShi YC, Yu CW, Liao VH, Pan TM (2012) Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. PLoS One 7, e39515.
10 µg/mlwhole life; start: L1OP50liquid S-mediumTK22 [mev-1(kn1)]20°CupyesA1; stressor: 250 µM juglone for 3.5 h; endpoint: survivalShi YC, Yu CW, Liao VH, Pan TM (2012) Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. PLoS One 7, e39515.
10 µg/mlwhole life; start: L1OP50liquid S-mediumCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CupyesA1; SOD-3 expression; similar change when pre-exposed to juglone; measured via fluorescenceShi YC, Yu CW, Liao VH, Pan TM (2012) Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. PLoS One 7, e39515.
10 µg/mlwhole life; start: L1OP50liquid S-mediumTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°CupyesA1; similar result with and without pre-exposure to jugloneShi YC, Yu CW, Liao VH, Pan TM (2012) Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. PLoS One 7, e39515.