Compound ID 296   (prev - next)

Name: Resveratrol (445154) (edit)

45 entries:
TreatmentResveratrolphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)445154ChEMBLCHEMBL165pharyngeal pumpinglocomotion in liquid mediabody length / growth ratenumber of offspringquantity of late reproductionquantity of early reproductiononset of egg layingheat stress resistanceoxidative stress resistanceautofluorescence (age pigment / lipofuscin)ROS levelactivity / quantity / expression of HSPsactivity / quantity / expression of SODsactivity / quantity / expression of GSTslevel of autophagytranslocation of SKN-1 to nucleustranslocation of DAF-16 to nucleusmedian lifespanmean lifespanmaximum lifespanminimum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
50 µMwhole life; start: egg stageOP50, heat-inactivatedNGM agarN2 (wild type)18°CnonenoA1 - A10nonenoA2 & A4downnoupyesA5 - A9down-20.00yesA0 - A4earlier-15.00yesnonenoStressor: 35°C; one experiment showed detrimental effects of resveratrol on heat resistanceup24.59yesA2; Stressor: 10 mM Paraquatup50.85yesup29.24yesup96.98n.d.Start of dying phaseGruber J, Tang SY, Halliwell B (2007) Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans. Ann N Y Acad Sci 1100, 530-542.
100 µg/mlwhole life; start: unknownOP50NGM agarN2 (wild type)20°CupyesMeasured with a DsRed::LGG-1 transgene reporter gene productup10.96n.d.up11.54n.d.sir-2.1 and the autophagy pathwayMorselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, Michaud M, Madeo F, Tavernarakis N, Kroemer G (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1:e10,
100 µg/mlwhole life; start: unknownOP50NGM agarVC199 [sir-2.1(ok434)]20°CnonenoMeasured with a DsRed::LGG-1 transgene reporter gene productMorselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, Michaud M, Madeo F, Tavernarakis N, Kroemer G (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1:e10,
100 µg/mlwhole life; start: unknownHT115 (DE3) with RNAi-vector against bec-1NGM agarIPTGN2 (wild type)20°Cdown-1.53n.dup09.09n.d.Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, Michaud M, Madeo F, Tavernarakis N, Kroemer G (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1:e10,
18 µMwhole life; start: A1OP50NGM agarN2 (wild type)20°Cdown-12.50yesA2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan; 1 out of 2 trials were significant; percentual change = average of 2 trialsBenedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
438 µMwhole life; start: A1OP50NGM agarN2 (wild type)20°Cdown-10.00yesA2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan; 1 out of 2 trials were significant; percentual change = average of 2 trialsBenedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
100 µMOP50-1NGM agarN2 (wild type)20°Cup14.2yespercentual change in a second trial: 14.6aak-2 / AMPKGreer EL, Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8, 113-127.
100 µMOP50-1NGM agarRB754 [aak-2(ok524)]20°Cup2.2noGreer EL, Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8, 113-127.
100 µMOP50-1NGM agarCF1038 [daf-16(mu86)]20°Cup13.7yesGreer EL, Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8, 113-127.
50 µMwhole life; start: L1OP50NGM agarTJ375 {gpIs1 [hsp-16.2p::GFP]}20°Cdown-25.2yesA1; pre-incubation: 20 µM juglone for 24 h; measurement via fluorescenceChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
100 µMwhole life; start: L1OP50NGM agarTJ375 {gpIs1 [hsp-16.2p::GFP]}20°Cdown-38.4yesA1; pre-incubation: 20 µM juglone for 24 h; measurement via fluorescenceChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
200 µMwhole life; start: L1OP50NGM agarTJ375 {gpIs1 [hsp-16.2p::GFP]}20°Cdown-40.7yesA1; pre-incubation: 20 µM juglone for 24 h; measurement via fluorescenceChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
50 µMwhole life; start: A1OP50NGM agarN2 (wild type)20°Cdown-0.4noChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
100 µMwhole life; start: A1OP50NGM agarN2 (wild type)20°Cdown-4.0noChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
200 µMwhole life; start: A1OP50NGM agarN2 (wild type)20°Cup0.5noChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
50 µMwhole life; start: A1OP50liquid S-mediumN2 (wild type)20°Cdown-3.9noChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
100 µMwhole life; start: A1OP50liquid S-mediumN2 (wild type)20°Cdown-18.6yesChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
200 µMwhole life; start: A1OP50liquid S-mediumN2 (wild type)20°Cdown-24.0yesChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
50 µMwhole life; start: A1OP50NGM agar50 mM glucoseN2 (wild type)20°Cup10.9yesChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
100 µMwhole life; start: A1OP50NGM agar50 mM glucoseN2 (wild type)20°Cup9.4noChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
200 µMwhole life; start: A1OP50NGM agar50 mM glucoseN2 (wild type)20°Cup16.0yesChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
50 µMwhole life; start: A1OP50NGM agarTK22 [mev-1(kn1)]20°Cdown-3.5noChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
100 µMwhole life; start: A1OP50NGM agarTK22 [mev-1(kn1)]20°Cdown-6.2noChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
200 µMwhole life; start: A1OP50NGM agarTK22 [mev-1(kn1)]20°Cdown-9.6yesChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
50 µMwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°Cup53.1yesA1; Stressor: 400 µM juglone; endpoint: mean lifespanChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
100 µMwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°Cup30.1yesA1; Stressor: 400 µM juglone; endpoint: mean lifespanChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
200 µMwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°Cup15.6yesA1; Stressor: 400 µM juglone; endpoint: mean lifespanChen W, Rezaizadehnajafi L, Wink M (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans. J Pharm Pharmacol 65, 682-688.
100 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup24.40yesUpadhyay A, Chompoo J, Taira N, Fukuta M, Tawata S (2013) Significant longevity-extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans. Biosci Biotechnol Biochem 77, 217-223.
100 µMwhole life; start: egg stageOP50NGM agarN2 (wild type)20°Cup12.99yesupyesChen Y, Onken B, Chen H, Xiao S, Liu X, Driscoll M, Cao Y, Huang Q (2014) Mechanism of longevity extension of Caenorhabditis elegans induced by pentagalloyl glucose isolated from eucalyptus leaves. J Agric Food Chem 62, 3422-3431.
100 µMwhole life; start: A1OP50, heat-inactivatedliquid NGMFUDRN2 (wild type)20°CnonenoA3; stressor: 37°C; endpoint: mean lifespandownnoA3; exposed to 37°C; measured via H2DCF-DAFischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µMwhole life; start: A1OP50, heat-inactivatedliquid NGMFUDRN2 (wild type)25°CupnoA11; unchanged at A18nonenoFischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µMwhole life; start: A1OP50, heat-inactivatedliquid NGMFUDRCF1038 [daf-16(mu86)]20°CdownyesA3; exposed to 37°C; measured via H2DCF-DA; significant change only during early time pointFischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µMwhole life; start: A1OP50, heat-inactivatedliquid NGMFUDREU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°CdownnoA3; exposed to 37°C; measured via H2DCF-DAFischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µMwhole life; start: A1OP50, heat-inactivatedliquid NGMFUDRVC199 [sir-2.1(ok434)]20°CnonenoA3; exposed to 37°C; measured via H2DCF-DAFischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µM1 h; start: A1OP50, heat-inactivatedliquid NGMFUDRTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°CnonenoA1Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µM1 h; start: A1OP50, heat-inactivatedliquid NGMFUDRLD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]}20°CnonenoA1Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
50 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinN2 (wild type)20°Cup7.88noA2; stressor: 37°C; endpoint: mean lifespan; similar change in median lifespanupnoA2; exposed to 37°C during measurement; measured via H2DCF-DABüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinN2 (wild type)20°Cup9.75yesA2; stressor: 37°C; endpoint: mean lifespan; similar change in median lifespandown-11.05yesA7; blue fluorescenceupnoA2; exposed to 37°C during measurement; measured via H2DCF-DABüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CdownyesA5; sod-3 expression; pre-exposed to juglone; unchanged without juglone exposure; measured via fluorescenceBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CdownyesA5; gst-4 expression; unchanged when pre-exposed to juglone; significant change without pre-exposure; measured via fluorescenceBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinN2 (wild type)25°Cup22.22n.d.up22.54yesBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinCF1038 [daf-16(mu86)]25°Cnonen.d.up8.69yesBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no