Treatment | Rhodiola rosea L root extract | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||
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CID (PubChem) | ChEMBL | heat stress resistance | oxidative stress resistance | UV stress resistance | activity / quantity / expression of HSPs | translocation of DAF-16 to nucleus | mean lifespan | maximum lifespan | minimum lifespan | |||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
2.5 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 1.91 | no | down | -6.67 | n.d. | down | -2.44 | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||
10 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 15.14 | yes | up | 12.44 | n.d. | up | 115.85 | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||
25 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 30.28 | yes | A4; Stressor: 35°C for 3 hours; Counting dead & alive 3 days after stress; when using 26°C as stressor, percentual change to control = 49.55 % | up | 3.40 | no | A4; Stressor: 10 mM Paraquat for 4 days | up | 38.18 | yes | A4; Stressor: UV with 1000 J/m2; Counting dead & alive 3 days after stress | up | 10.77 | yes | up | 8.44 | n.d. | up | 107.32 | n.d. | DAF-16; HSP-16.2 | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | |||||||||||||||
50 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 3.76 | yes | up | 8.00 | n.d. | down | -2.44 | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||
100 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | down | -3.3 | no | down | -9.78 | n.d. | down | -2.44 | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | down | -13.98 | yes | down | -15.56 | n.d. | down | -14.63 | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||
10 µg/ml | whole life; start: A5 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 11.5 | yes | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||
25 µg/ml | whole life; start: A5 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 8.00 | yes | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||
50 µg/ml | whole life; start: A5 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | none | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||||
25 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | 20°C | up | 3.21 | no | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||
25 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | |||||||||||||||||||||||||||||||||||
50 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | |||||||||||||||||||||||||||||||||||
100 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | |||||||||||||||||||||||||||||||||||
25 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20°C | none | n.d. | Quantification via Westernblot | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||
50 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20°C | up | n.d. | Quantification via Westernblot | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. |