Treatment | 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) from Curcuma longa L | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||
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CID (PubChem) | 65238 | ChEMBL | heat stress resistance | oxidative stress resistance | ROS level | activity / quantity / expression of SODs | mean lifespan | |||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
50 µM | whole life; start: egg stage | OP50 | NGM agar | N2 (wild type) | 20°C | up | yes | A4; Stressor: 36°C for 16 h; endpoint: mean lifespan | up | yes | A7; Stressor: 60 mM paraquat; endpoint: mean lifespan | down | no | A4; pre-exposed to 60 mM paraquat for 3 h; measured via H2-DCF-DA | up | no | A5; SOD-activity determined with the aid of formazan | up | yes | Ahn D, Cha DS, Lee EB, Kim BJ, Lee SY, Jeon H, Ahn MS, Lim HW, Lee HY, Kim DK (2013) The Longevity Properties of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose from Curcuma longa in Caenorhabditis elegans. Biomol Ther (Seoul) 21, 442-446. | ||||||||||||
100 µM | whole life; start: egg stage | OP50 | NGM agar | N2 (wild type) | 20°C | up | 23.00 | yes | A4; Stressor: 36°C for 16 h; endpoint: mean lifespan | up | yes | A7; Stressor: 60 mM paraquat; endpoint: mean lifespan | down | yes | A4; pre-exposed to 60 mM paraquat for 3 h; measured via H2-DCF-DA | up | yes | A5; SOD-activity determined with the aid of formazan | up | 15.70 | yes | Ahn D, Cha DS, Lee EB, Kim BJ, Lee SY, Jeon H, Ahn MS, Lim HW, Lee HY, Kim DK (2013) The Longevity Properties of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose from Curcuma longa in Caenorhabditis elegans. Biomol Ther (Seoul) 21, 442-446. |