Compound ID 300 (prev - next)

Name: Rosmarinus officinalis L. (ethanolic extract) (65126) (edit)

15 entries:

Treatment	Rosmarinus officinalis L. (ethanolic extract)						physiological function								healthspan biomarkers								lifespan								Target	Reference
CID (PubChem)	65126	ChEMBL					heat stress resistance				oxidative stress resistance				ROS level				translocation of DAF-16 to nucleus				median lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
10 µg/mL	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C	none		no	A1; stressor: 35°C for 4 h; endpoint: survival	up		no	A1; stressor: 100 µM juglone for 1 h; endpoint: survival	down		yes	A1; pre-exposed to 25 mM H2O2 for 1 h; similar result without pre-exposure; measured via H2DCF-DA					none		no		up	6.25	no			Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.
25 µg/mL	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C	up		yes	A1; stressor: 35°C for 4 h; endpoint: survival	up		yes	A1; stressor: 100 µM juglone for 1 h; endpoint: survival	down		yes	A1; pre-exposed to 25 mM H2O2 for 1 h; similar result without pre-exposure; measured via H2DCF-DA					up	25.00	yes		up	25.00	yes		insulin like signaling pathway, DAF-16, HSF-1, and SKN-1	Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.
50 µg/mL	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C	up		yes	A1; stressor: 35°C for 4 h; endpoint: survival	up		yes	A1; stressor: 100 µM juglone for 1 h; endpoint: survival	down		yes	A1; pre-exposed to 25 mM H2O2 for 1 h; similar result without pre-exposure; measured via H2DCF-DA					up	8.33	no		up	6.25	no			Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.
100 µg/mL	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C	down		no	A1; stressor: 35°C for 4 h; endpoint: survival	down		no	A1; stressor: 100 µM juglone for 1 h; endpoint: survival																		Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.
10 µg/mL	whole life; start: L1	OP50	NGM agar		TK22 [mev-1(kn1)]	20°C									down		yes	A1; measured via H2DCF-DA														Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.
25 µg/mL	whole life; start: L1	OP50	NGM agar		TK22 [mev-1(kn1)]	20°C									down		yes	A1; measured via H2DCF-DA					up	20.00	yes		up	12.5	yes			Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.
50 µg/mL	whole life; start: L1	OP50	NGM agar		TK22 [mev-1(kn1)]	20°C									down		yes	A1; measured via H2DCF-DA														Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.
25 µg/ml	whole life; start: L1	OP50	NGM agar		CB1370 [daf-2(e1370)]	16°C																	none		no		up	6.67	yes			Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.
25 µg/mL	whole life; start: L1	OP50	NGM agar		CF1038 [daf-16(mu86)]	20°C	up		no	A1; stressor: 35°C for 4 h; endpoint: survival	up		no	A1; stressor: 100 µM juglone for 1 h; endpoint: survival	down		yes	A1; measured via H2DCF-DA					up	20.00	yes		up	7.14	no			Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.
25 µg/mL	whole life; start: L1	OP50	NGM agar		PS3551 [hsf-1(sy441)]	20°C	up		no	A1; stressor: 35°C for 4 h; endpoint: survival	none		no	A1; stressor: 100 µM juglone for 1 h; endpoint: survival	down		yes	A1; measured via H2DCF-DA					none		no		up	7.69	no			Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.
25 µg/mL	whole life; start: L1	OP50	NGM agar		EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]	20°C	none		no	A1; stressor: 35°C for 4 h; endpoint: survival	up		no	A1; stressor: 100 µM juglone for 1 h; endpoint: survival	down		yes	A1; measured via H2DCF-DA					up	11.11	no		none		no			Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.
N/A	whole life; start: L1	OP50	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C													none													Zamberlan DC, Amaral GP, Arantes LP, Machado ML, Mizdal CR, Campos MM, Soares FA (2016) Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res 49, e5235.