Compound ID 305 (prev - next)

Name: S-allylmercaptocysteine (9794159) (edit)

22 entries:

Treatment	S-allylmercaptocysteine						physical function								reproductive function												physiological function								healthspan biomarkers																																lifespan								Transcriptome	Proteome	Target	Reference
CID (PubChem)	9794159	ChEMBL					food consumption				body length / growth rate				number of offspring				quantity of late reproduction				quantity of early reproduction				heat stress resistance				oxidative stress resistance				ROS level				activity / quantity / expression of HSPs				activity / quantity / expression of SODs				activity / quantity / expression of CTLs				activity / quantity / expression of GSTs				proteasomal activity				translocation of SKN-1 to nucleus				translocation of DAF-16 to nucleus				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
1 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	FUDR, amphotericin B	N2 (wild type)	20°C																																																													up	5.80	yes		none		no					Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
10 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	FUDR, amphotericin B	N2 (wild type)	20°C	up		yes	A8	none		no	A8													up		yes	A3; stressor: 35 °C for 7 h; endpoint: survival	up	463.75	yes	A3; stressor: 250 µM juglone for 2 h; endpoint: survival	down		yes	A3; pre-exposed to to 35°C for 7 h or 250 µM juglone for 2 h; no change without pre-exposure													up		variable	A2; expression of gst-4; measured via qRT-PCR; no significant up-regulation of gst-10													up	19.70	yes		up	26.44	no				SKN-1	Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
100 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	FUDR, amphotericin B	N2 (wild type)	20°C																																									none		no	A2; expression of ctl-2; measured via qRT-PCR	up		yes	A2; expression of gst-4; measured via qRT-PCR; no significant up-regulation of gst-10													up	20.90	yes		up	7.76	no		up-regulation of gst-4, gcs-1, atf-5, and pas-4		SKN-1	Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
10 µM	whole life; start: L1	OP50, UV-inactivated	liquid S-medium	amphotericin B	N2 (wild type)	20°C																																																	none		no	A2																				Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
10 µM	whole life; start: L4	OP50, UV-inactivated	liquid S-medium	amphotericin B	N2 (wild type)	20°C									none		no		down		yes		up		yes																																																			up-regulation of SKN-1		Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
10 µM	whole life; start: A1	HT115 (DE3) with RNAi-vector against wdr-23	liquid S-medium	FUDR, amphotericin B, ampicillin, IPTG	N2 (wild type)	20°C																																													none		no	A2; expression of gst-4; measured via qRT-PCR																								Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
100 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	amphotericin B	CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}	20°C																																					none		no	A2; expression of sod-3; measured via fluorescence; also no change in mRNA level measured via qRT-PCR																																Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
100 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	amphotericin B	CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}	20°C																																	none		no	A2; measured via fluorescence; also no change in mRNA level measured via qRT-PCR																																				Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
10 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	amphotericin B	CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}	20°C																																													up	710.00	yes	A2; expression of gst-4; measured via fluorescence																								Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
1 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	FUDR, amphotericin B	unknown strain [daf-16(mgDf47)]	20°C																																																													down	-1.20	no		up	6.95	no					Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
10 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	FUDR, amphotericin B	unknown strain [daf-16(mgDf47)]	20°C																																																													up	11.10	yes		up	12.30	no					Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
100 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	FUDR, amphotericin B	unknown strain [daf-16(mgDf47)]	20°C																																																													up	14.50	yes		up	6.95	no					Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
100 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	amphotericin B	LD1482 {daf-16(mu86); Is[DAF-16A::GFP]}	20°C																																																									none		no	A2												Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
10 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	amphotericin B	CL691 {dvIs19 [(pAF15) gst-4p::GFP::NLS]; skn-1(zu67) IV/nT1 [unc-?(n754) let-?]}	20°C																																													none		no	A2; expression of gst-4; measured via fluorescence																								Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
10 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	FUDR, amphotericin B	EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]	20°C																																																													up	0.90	no		up	8.90	no					Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
100 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	FUDR, amphotericin B	EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]	20°C																																																													down	-12.30	yes		down	-17.80	no					Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
10 µM	whole life; start: parental generation	OP50, UV-inactivated	liquid S-medium	amphotericin B	LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]}	20°C																																																					up		yes	L4; pre-exposed to NaN3																Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
10 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	FUDR, amphotericin B	KU4 [sek-1(km4)]	20°C																																													up		no	A2; expression of gst-4; measured via qRT-PCR																								Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.
100 µM	whole life; start: A1	OP50, UV-inactivated	liquid S-medium	FUDR, amphotericin B	KU4 [sek-1(km4)]	20°C																																													up		yes	A2; expression of gst-4; measured via qRT-PCR																								Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611.