Compound ID 317 (prev - next)

Name: Salicylamine (70267) (edit)

12 entries:

Treatment	Salicylamine						physical function				healthspan biomarkers																lifespan				Target	Reference	blinded
CID (PubChem)	70267	ChEMBL	155572				pharyngeal pumping				autofluorescence (age pigment / lipofuscin)				F3-isoprostane level				oxygen consumption rate (OCR)				mitochondrial DNA (mtDNA) integrity				median lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
50 µM	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																					up	18.00	No		sir-2.1, ets-7	Nguyen et al. (2016) Scavengers of reactive γ‐ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein‐level interactions with SIR‐2.1 and ETS‐7. Aging 8, 1759-1780	no
100 µM	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	N2 (wild type)	20°C	up		Yes	A20 (not significant in A5, A10 & A15)	down		Yes	Measured every 5th day; blue fluorescence	down	-29	Yes	A15	down		No	A15 (OCR unchanged in A2)	down		No	A2 & A15	up	32.00	Yes		sir-2.1, ets-7	Nguyen et al. (2016) Scavengers of reactive γ‐ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein‐level interactions with SIR‐2.1 and ETS‐7. Aging 8, 1759-1780	no
500 µM	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	N2 (wild type)	20°C	up		Yes	A20 (not significant in A5, A10 & A15)	down		Yes	Measured every 5th day; blue fluorescence	down	-44	Yes	A15	down		No	A15 (OCR unchanged in A2)	down		No	A2 (unchanged in A15)	up	56.00	Yes		sir-2.1, ets-7	Nguyen et al. (2016) Scavengers of reactive γ‐ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein‐level interactions with SIR‐2.1 and ETS‐7. Aging 8, 1759-1780	no
50 µM	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	20°C																					none		no			Nguyen et al. (2016) Scavengers of reactive γ‐ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein‐level interactions with SIR‐2.1 and ETS‐7. Aging 8, 1759-1780	no
100 µM	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	20°C	none		no	A5, A10, A15 & A20	none		no	blue fluorescence	none		no	A15	none		no	A2 & A15	none		no	A2 & A15	none		no			Nguyen et al. (2016) Scavengers of reactive γ‐ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein‐level interactions with SIR‐2.1 and ETS‐7. Aging 8, 1759-1780	no
500 µM	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	20°C	none		no	A5, A10, A15 & A20	none		no	blue fluorescence	none		no	A15	none		no	A2 & A15	none		no	A2 & A15	none		no			Nguyen et al. (2016) Scavengers of reactive γ‐ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein‐level interactions with SIR‐2.1 and ETS‐7. Aging 8, 1759-1780	no
50 µM	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	RB981 [ets-7(ok888)]	20°C																					down		no			Nguyen et al. (2016) Scavengers of reactive γ‐ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein‐level interactions with SIR‐2.1 and ETS‐7. Aging 8, 1759-1780	no
100 µM	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	RB981 [ets-7(ok888)]	20°C																					down		no			Nguyen et al. (2016) Scavengers of reactive γ‐ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein‐level interactions with SIR‐2.1 and ETS‐7. Aging 8, 1759-1780	no
500 µM	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	RB981 [ets-7(ok888)]	20°C																					down		no			Nguyen et al. (2016) Scavengers of reactive γ‐ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein‐level interactions with SIR‐2.1 and ETS‐7. Aging 8, 1759-1780	no