Treatment | Sesame cake peptides | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||||||||||||||||||||||||||||||||
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CID (PubChem) | ChEMBL | pharyngeal pumping | locomotion on solid media | heat stress resistance | oxidative stress resistance | autofluorescence (age pigment / lipofuscin) | ROS level | activity / quantity / expression of SODs | activity / quantity / expression of CTLs | GSH level | mean lifespan | maximum lifespan | ||||||||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
12.5 µg/ml | whole life; start: L4 | OP50, killed | NGM agar | FUDR | N2 (wild type) | 20°C | up | yes | A4 & A8 | up | A8 (unchanged in A4) | none | A4; Stressor: 37°C | up | 38.90 | yes | A4; Stressor: Juglone | down | yes | A10; green fluorescence | down | yes | A2 | up | 145.60 | yes | A2 | down | 6.20 | A2 | up | 91.5 | yes | A2 | up | 15.60 | yes | up | 3.57 | skn-1/Nrf-2 | Wang Z, Ma X, Li J, Cui X (2016) Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels. Exp Gerontol 82, 139-149 | no | ||||||||||||||
25 µg/ml | whole life; start: L4 | OP50, killed | NGM agar | FUDR | N2 (wild type) | 20°C | up | 13.30 | yes | up | 3.57 | Wang Z, Ma X, Li J, Cui X (2016) Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels. Exp Gerontol 82, 139-149 | no | |||||||||||||||||||||||||||||||||||||||||||
50 µg/ml | whole life; start: L4 | OP50, killed | NGM agar | FUDR | N2 (wild type) | 20°C | up | 5.20 | yes | up | 3.57 | Wang Z, Ma X, Li J, Cui X (2016) Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels. Exp Gerontol 82, 139-149 | no | |||||||||||||||||||||||||||||||||||||||||||
12.5 µg/ml | whole life; start: L4 | OP50, killed | NGM agar | FUDR | TK22 [mev-1(kn1)] | 20°C | up | 14.29 | yes | none | Wang Z, Ma X, Li J, Cui X (2016) Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels. Exp Gerontol 82, 139-149 | no | ||||||||||||||||||||||||||||||||||||||||||||
12.5 µg/ml | whole life; start: L4 | OP50, killed | NGM agar | FUDR | DA465 [eat-2(ad465)] | 20°C | up | 12.34 | yes | up | 2.70 | Wang Z, Ma X, Li J, Cui X (2016) Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels. Exp Gerontol 82, 139-149 | no | |||||||||||||||||||||||||||||||||||||||||||
12.5 µg/ml | whole life; start: L4 | OP50, killed | NGM agar | FUDR | EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]] | 20°C | none | -0.81 | no | down | -4.35 | Wang Z, Ma X, Li J, Cui X (2016) Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels. Exp Gerontol 82, 139-149 | no | |||||||||||||||||||||||||||||||||||||||||||
12.5 µg/ml | whole life; start: L4 | OP50, killed | NGM agar | FUDR | PS3551 [hsf-1(sy441)] | 20°C | up | 9.63 | yes | up | 5.00 | Wang Z, Ma X, Li J, Cui X (2016) Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels. Exp Gerontol 82, 139-149 | no | |||||||||||||||||||||||||||||||||||||||||||
12.5 µg/ml | whole life; start: L4 | OP50, killed | NGM agar | FUDR | CF1038 [daf-16(mu86)] | 20°C | up | 9.63 | yes | up | 5.00 | Wang Z, Ma X, Li J, Cui X (2016) Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels. Exp Gerontol 82, 139-149 | no |