Compound ID 324 (prev - next)

Name: Silymarin (31553) (edit)

10 entries:

Treatment	Silymarin						physical function				physiological function								lifespan				Reference
CID (PubChem)	31553	ChEMBL					locomotion on solid media				heat stress resistance				oxidative stress resistance				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
10 µM	whole life; start: parental generation	OP50, UV-inactivated	NGM agar		N2 (wild type)	20°C													up	4.55	yes		Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267.
50 µM	whole life; start: parental generation	OP50, UV-inactivated	NGM agar		N2 (wild type)	20°C													up	13.64	yes		Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267.
25 µM	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20°C	up	44.85	yes	A10; endpoint: spontaneous movement; no significant change in number of body bends at A5	up	23.59	yes	A5: stressor: 35°C for 4 h; endpoint: survival					up	10.08	yes		Kumar J, Park KC, Awasthi A, Prasad B (2015) Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer's model. CNS Neurol Disord Drug Targets 14, 295-302.
50 µM	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20°C	up	82.47	yes	A10; endpoint: spontaneous movement; significantly increased number of body bends at A5 (+29.47%)	up	42.21	yes	A5: stressor: 35°C for 4 h; endpoint: survival					up	24.80	yes		Kumar J, Park KC, Awasthi A, Prasad B (2015) Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer's model. CNS Neurol Disord Drug Targets 14, 295-302.
100 µM	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20°C	down	-25.26	yes	A10; endpoint: spontaneous movement; no significant change in number of body bends at A5	down	-25.76	yes	A5: stressor: 35°C for 4 h; endpoint: survival					down	-8.95	yes		Kumar J, Park KC, Awasthi A, Prasad B (2015) Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer's model. CNS Neurol Disord Drug Targets 14, 295-302.
25 µM	whole life; start: L4	OP50	NGM agar		CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C	up		yes	pre-exposed to 25°C for 18-20 h; endpoint: ratio of non-paralyzed and paralyzed worms													Kumar J, Park KC, Awasthi A, Prasad B (2015) Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer's model. CNS Neurol Disord Drug Targets 14, 295-302.
50 µM	whole life; start: L4	OP50	NGM agar		CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C	up		yes	pre-exposed to 25°C for 18-20 h; endpoint: ratio of non-paralyzed and paralyzed worms					up		yes	pre-exposed to 25°C; stressor: 10 mM paraquat; endpoint: motility					Kumar J, Park KC, Awasthi A, Prasad B (2015) Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer's model. CNS Neurol Disord Drug Targets 14, 295-302.