Treatment | Sophora moorcroftiana, extract decoction | physical function | reproductive function | physiological function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||||||||||||||||||||
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CID (PubChem) | ChEMBL | pharyngeal pumping | locomotion on solid media | number of offspring | speed of larval development | heat stress resistance | oxidative stress resistance | pathogen stress resistance | mean lifespan | |||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
4 mg/ml | start: L1; stop: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | none | no | up | 6,9 | no | none | no | up | yes | L4; stressor: 35°C; endpoint: survival | up | yes | L4; stressor: H2O2; endpoint: survival | up | yes | L4; stressor: P. aeruginosa for 8h; endpoint: survival; reduced bacterial colonization | up | 18,7 | no | Zhang, Y., Mi, D. Y., Wang, J., Luo, Y. P., Yang, X., Dong, S., Ma, X. M., & Dong, K. Z. (2018). Constituent and effects of polysaccharides isolated from Sophora moorcroftiana seeds on lifespan, reproduction, stress resistance, and antimicrobial capacity in Caenorhabditis elegans. Chinese journal of natural medicines, 16(4), 252–260. https://doi.org/10.1016/S1875-5364(18)30055-4 |