Treatment | Soybean trypsin inhibitor | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | 49777573 | ChEMBL | mean lifespan | maximum lifespan | ||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
2.5 µM | whole life; start: L4/A1 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 8.67 | no | up | 2.94 | n.d. | Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71. | |||||||
5 µM | whole life; start: L4/A1 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 8.67 | yes | up | 5.51 | n.d. | Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71. | |||||||
10 µM | whole life; start: L4/A1 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 10.40 | yes | up | 8.46 | n.d. | Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71. |