Compound ID 330   (prev - next)

Name: TSG (2,3,5,4󸀠-Tetrahydroxystilbene-2-O-𝛽-D-glucoside) from Polygonum multiflorum (5321884) (edit)

9 entries:
TreatmentTSG (2,3,5,4󸀠-Tetrahydroxystilbene-2-O-𝛽-D-glucoside) from Polygonum multiflorumphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)5321884ChEMBLheat stress resistanceautofluorescence (age pigment / lipofuscin)ROS levelactivity / quantity / expression of SODsactivity / quantity / expression of GSTsmedian lifespanmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
50 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinN2 (wild type)20°Cup22.20yesA2; stressor: 37°C; endpoint: mean lifespan; similar change in median lifespannonenoA2; exposed to 37°C during measurement; measured via H2DCF-DABüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinN2 (wild type)20°Cup23.24yesA2; stressor: 37°C; endpoint: mean lifespan; similar change in median lifespandown-20.00yesA7; blue fluorescencedown-10.40variableA2; exposed to 37°C during measurement; measured via H2DCF-DA; significant changes only after 60 minutesBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinN2 (wild type)25°Cup22.22n.d.up21.56yesBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinCF1038 [daf-16(mu86)]25°Cup9.09n.d.up10.50yesBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°Cdown-23.91yesA5; sod-3 expression; pre-exposed to juglone; unchanged without juglone exposure; measured via fluorescenceBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no
100 µMwhole life; start: L4OP50-1liquid NGMBSA, streptomycinCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CdownyesA5; gst-4 expression; unchanged when pre-exposed to juglone; significant change without pre-exposure; measured via fluorescenceBüchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015) TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxid Med Cell Longev 2015:124357. no