| Treatment | Tianma wan (TCM formula) | reproductive function | physiological function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | number of offspring | heat stress resistance | oxidative stress resistance | median lifespan | mean lifespan | ||||||||||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 11.5 g/l | whole life; start: L4 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | n.d. | down | -0.3 | n.d. | up | 6.10 | no | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||||||
| 23 g/l | whole life; start: L4 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | n.d. | up | 22.20 | n.d. | up | 26.00 | yes | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||||||
| 23 g/l | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | n.d. | up | 9.00 | n.d. | up | 3.70 | no | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||||||
| 23 g/l | whole life; start: L1 | OP50 | NGM agar | FUDR | N2 (wild type) | n.d. | down | yes | down | -81.77 | yes | A1; stressor: 35°C for 22.5 h; endpoint: survival | down | -15.57 | no | L1; stressor: 10 mM paraquat; endpoint: survival after 3.5 days | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||
| 23 g/l | whole life; start: L1 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | n.d. | down | no | up | 219.14 | yes | A1; stressor: 35°C for 28 h; endpoint: survival | up | 80.65 | yes | L1; stressor: 10 mM paraquat; endpoint: survival after 3.5 days | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||