Compound ID 336 (prev - next)

Name: Tomatidine (65576) (edit)

11 entries:

Treatment	Tomatidine						physical function												physiological function								healthspan biomarkers												lifespan				Transcriptome	Metabolome	Target	Reference
CID (PubChem)	65576	ChEMBL	CHEMBL2165711	GEO	GSE85237		pharyngeal pumping				locomotion in liquid media				locomotion on solid media				heat stress resistance				oxidative stress resistance				oxygen consumption rate (OCR)				mitochondrial content/quality				muscle integrity				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
10 µM	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	25°C									down		no	A10									up		yes	A4 (unchanged in A1)																Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG (2017) Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Sci Rep. 7, 46208.
25 µM	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	25°C	up		yes	A5 & A7	up	48.00	yes	A12 (unchanged in A5)	none		no	A10									up		yes	A4 (unchanged in A1)	up		yes		up			A8 (unchanged in A4)	up	7.00	yes		available in the supplements	available in the supplements	dct-1, pink-1, SKN-1/Nrf2-pathway	Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG (2017) Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Sci Rep. 7, 46208.
50 µM	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	25°C									down		no	A10																					none							Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG (2017) Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Sci Rep. 7, 46208.
50 µM	whole life; start: L4	HT115 (DE3)	NGM agar	FUDR	N2 (wild type)	25°C	up		yes	A5 & A9									up		yes	A4; Stressor: 37 °C for 7 h	up		yes	A6; Stressor: 25 µM Rotenone for 2 days (from A4-A6)																				Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG (2017) Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Sci Rep. 7, 46208.
25 µM	whole life; start: L4	HT115 (DE3) with RNAi-vector against dct-1	NGM agar	FUDR	N2 (wild type)	25°C	none		no	A5 & A9									none		no	A4; Stressor: 37 °C for 7 h	none		no	A6; Stressor: 25 µM Rotenone for 2 days (from A4-A6)																				Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG (2017) Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Sci Rep. 7, 46208.
25 µM	whole life; start: L4	HT115 (DE3) with RNAi-vector against pink-1	NGM agar	FUDR	N2 (wild type)	25°C													none		no	A4; Stressor: 37 °C for 7 h	none		no	A6; Stressor: 25 µM Rotenone for 2 days (from A4-A6)																				Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG (2017) Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Sci Rep. 7, 46208.
25 µM	whole life; start: L4	HT115 (DE3) with RNAi-vector against atfs-1	NGM agar	FUDR	N2 (wild type)	25°C	none		no	A5																																				Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG (2017) Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Sci Rep. 7, 46208.
25 µM	whole life; start: L4	OP50	NGM agar	FUDR	EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]	25°C	none		no	A5 & A7																																				Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG (2017) Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Sci Rep. 7, 46208.