100 µM | whole life; start: L4 | OP50, ethanol- and UV-inactivated | NGM agar | FUDR | N2 (wild type) | 20°C | up | 84.58 | yes | A10; non-significantly decreased at A1; unchanged at A5 and A15 | none | | no | A1, A5, A10, and A15; endpoint: number of body bends | up | 22.60 | yes | | | | | | Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266. | |
100 µM | whole life; start: L4 | OP50, ethanol- and UV-inactivated | NGM agar | FUDR | DA465[eat-2(ad465)] | 20°C | | | | | | | | | up | 4.20 | variable | | | | | | Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266. | |
200 µM | whole life; start: L4 | OP50, ethanol- and UV-inactivated | NGM agar | FUDR | N2 (wild type) | 20°C | | | | | | | | | up | 23.80 | yes | | | | | | Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266. | |
200 µM | whole life; start: L4 | OP50, ethanol- and UV-inactivated | NGM agar | FUDR | DA465[eat-2(ad465)] | 20°C | | | | | | | | | up | 3.60 | yes | | | | | | Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266. | |
100 µM | whole life; start: L4 | OP50, ethanol- and UV-inactivated | NGM agar | FUDR | GR1307 [daf-16(mgDf50)] | 20°C | | | | | | | | | up | 23.8 | yes | | | | | | Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266. | |