Compound ID 338   (prev - next)

Name: Trichostatin A (444732) (edit)

8 entries:
TreatmentTrichostatin Aphysical functionlifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)444732ChEMBLCHEMBL99pharyngeal pumpinglocomotion on solid mediamean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
100 µMwhole life; start: L4OP50, ethanol- and UV-inactivatedNGM agarFUDRN2 (wild type)20°Cup84.58yesA10; non-significantly decreased at A1; unchanged at A5 and A15nonenoA1, A5, A10, and A15; endpoint: number of body bendsup22.60yesCalvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.
100 µMwhole life; start: L4OP50, ethanol- and UV-inactivatedNGM agarFUDRDA465[eat-2(ad465)]20°Cup4.20variableCalvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.
200 µMwhole life; start: L4OP50, ethanol- and UV-inactivatedNGM agarFUDRN2 (wild type)20°Cup23.80yesCalvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.
200 µMwhole life; start: L4OP50, ethanol- and UV-inactivatedNGM agarFUDRDA465[eat-2(ad465)]20°Cup3.60yesCalvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.
100 µMwhole life; start: L4OP50, ethanol- and UV-inactivatedNGM agarFUDRGR1307 [daf-16(mgDf50)]20°Cup23.8yesCalvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.