Compound ID 340 (prev - next)

Name: Trolox (40634) (edit)

14 entries:

Treatment	Trolox						reproductive function				physiological function				healthspan biomarkers												lifespan								Target	Reference
CID (PubChem)	40634	ChEMBL					number of offspring				heat stress resistance				activity / quantity / expression of SODs				activity / quantity / expression of GSTs				activity / quantity / expression of CYPs				median lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
116 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C					down	-4.81	variable	A2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan																						Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
200 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C					up	14.40	yes	A2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan																						Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
579 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C					up	1.02	variable	A2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan																						Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
1 mM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C					up	5.01	no	A2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan													up	35.71	yes		up	18.01	yes	90th percentile survival		Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
2.9 mM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C					up	10.60	variable	A2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan																						Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
600 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C																					up	13.33	yes		up	8.87	n.d.	90th percentile survival		Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
3 mM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C	down	-7.72	no																		up	37.50	yes		up	15.96	variable	90th percentile survival	cyp-35A3	Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
500 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C	down	-5.79	no																											Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
3 mM	whole life; start: A1	OP50	NGM agar		CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}	20°C													up		no	A2; measured via fluorescence														Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
3 mM	whole life; start: A1	OP50	NGM agar		CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}	20°C									up		no	A2; measured via fluorescence																		Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
3 mM	whole life; start: A1	OP50	NGM agar		unknown strain [cyp-35::GFP]	20°C																	up		yes	A2; measured via fluorescence										Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.