Compound ID 343   (prev - next)

Name: Tyrosol (10393) (edit)

22 entries:
TreatmentTyrosolcognitive functionphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)10393ChEMBLneuronal survival / integritypharyngeal pumpinglocomotion in liquid mediabody length / growth ratenumber of offspringvertex (progeny per day)speed of larval developmentonset of egg layingheat stress resistanceoxidative stress resistanceROS levelquantity of α-synucleintranslocation of DAF-16 to nucleusmedian lifespanmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
100 µMwhole life; start: egg stageOP50NGM agarDH26 [fer-15(b26)]25°Cupn.d.up6.86noCañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A (2012)Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev 133, 563-574.
250 µMwhole life; start: egg stageOP50NGM agarDH26 [fer-15(b26)]25°CupyesA2 - A9; no significant change at A1downyesL4; no significant changes at A1 and A5up55.43yesA5; stressor: 35°C for 8 h; endpoint: survivalupyesA1; stressor: 4 mM paraquat; endpoint: mean lifespanup20.63yesup21.13yesup10.76yesA4: up-regulation of hsp-12.6A4: up-regulation of GEI-7, EF-2, SAHH, ENPL-1, VHA-12, VHA-13, GST-4; down-regulation of VIT-2, RAN-1, ACDH-3, ADH-1. Isoform distribution changed in VIT-5 and HSP-4Cañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A (2012)Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev 133, 563-574.
1 mMwhole life; start: egg stageOP50NGM agarDH26 [fer-15(b26)]25°Cupn.d.up5.44noCañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A (2012)Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev 133, 563-574.
2.5 mMwhole life; start: egg stageOP50NGM agarDH26 [fer-15(b26)]25°Cupn.d.up4.85noCañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A (2012)Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev 133, 563-574.
250 µMwhole life; start: egg stageOP50NGM agarN2 (wild type)25°Cnonenononenononen.d.nonen.d.upyesA5; stressor: 35°C for 8 h; endpoint: survivalupyesA1; stressor: 4 mM paraquat; endpoint: mean lifespanup15.38yesup16.55yesup-regulation of hsp-12.6DAF-16 and HSF-1Cañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A (2012)Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev 133, 563-574.
250 µMwhole life; start: L1OP50NGM agarTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°CupyesL4; intermediate nuclear translocationCañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A (2012)Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev 133, 563-574.
250 µMwhole life; start: egg stageOP50NGM agarTK22 [mev-1(kn1)]20°CupyesA1; stressor: 4 mM paraquat; endpoint: mean lifespanup11.11noup4.69noCañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A (2012)Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev 133, 563-574.
250 µMwhole life; start: egg stageOP50NGM agarVC199 [sir-2.1(ok434)]20°Cup9.09yesup9.36yesCañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A (2012)Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev 133, 563-574.
250 µMwhole life; start: egg stageOP50NGM agarGM11 [daf-16(m26); fer-15(b26)]20°CnonenoA5; stressor: 35°C for 8 h; endpoint: survivalnonenoA1; stressor: 4 mM paraquat; endpoint: mean lifespanup7.69noup1.46noCañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A (2012)Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev 133, 563-574.
250 µMwhole life; start: egg stageOP50NGM agarGM6 [fer-15(b26); daf-2(e1370)]20°CupyesA5; stressor: 35°C for 8 h; endpoint: survivalnonenoA1; stressor: 4 mM paraquat; endpoint: mean lifespanup2.44noup6.13noCañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A (2012)Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev 133, 563-574.
250 µMwhole life; start: egg stageOP50NGM agarPS3551 [hsf-1(sy441)]20°CnonenoA5; stressor: 35°C for 8 h; endpoint: survivalnonenoA1; stressor: 4 mM paraquat; endpoint: mean lifespannonenoup7.43noCañuelo A, Gilbert-López B, Pacheco-Liñán P, Martínez-Lara E, Siles E, Miranda-Vizuete A (2012)Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev 133, 563-574.
50 µMwhole life; start: A1OP50liquid S-mediumFUdR, penicillin, streptomycinNL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}20°CnonenoGarcia-Moreno JC, Porta de la Riva M, Martínez-Lara E, Siles E, Cañuelo A (2019) Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease. Neurobiol Aging 82, 60-68. no
250 µMwhole life; start: A1OP50liquid S-mediumFUdR, penicillin, streptomycinNL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}20°CnonenoGarcia-Moreno JC, Porta de la Riva M, Martínez-Lara E, Siles E, Cañuelo A (2019) Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease. Neurobiol Aging 82, 60-68. no
500 µMwhole life; start: A1OP50liquid S-mediumFUdR, penicillin, streptomycinNL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}20°CnonenoGarcia-Moreno JC, Porta de la Riva M, Martínez-Lara E, Siles E, Cañuelo A (2019) Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease. Neurobiol Aging 82, 60-68. no
1000 µMwhole life; start: A1OP50liquid S-mediumFUdR, penicillin, streptomycinNL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}20°Cdown-34.1yesA6; measured via H2DCF-DAup14.2yesGarcia-Moreno JC, Porta de la Riva M, Martínez-Lara E, Siles E, Cañuelo A (2019) Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease. Neurobiol Aging 82, 60-68. no
1000 µMwhole life; start: L4OP50NGM agarFUdR, penicillin, streptomycinNL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}20°CupyesA9; no significance at A3, A7, A11down-61.5yesA6; via fluorescence; not confirmed via western blotGarcia-Moreno JC, Porta de la Riva M, Martínez-Lara E, Siles E, Cañuelo A (2019) Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease. Neurobiol Aging 82, 60-68. no
1000 µMwhole life; start: A1OP50NGM agarFUdR, penicillin, streptomycinN2 (wild type)20°CnonenoA3, A7, A9, A11Garcia-Moreno JC, Porta de la Riva M, Martínez-Lara E, Siles E, Cañuelo A (2019) Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease. Neurobiol Aging 82, 60-68. no
1000 µMwhole life; start: A1OP50NGM agarFUdR, penicillin, streptomycinUA44 {baIn11 [dat-1p::α-synuclein, dat-1p::GFP]}20°CupyesA14Garcia-Moreno JC, Porta de la Riva M, Martínez-Lara E, Siles E, Cañuelo A (2019) Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease. Neurobiol Aging 82, 60-68. no
1000 µMwhole life; start: L1OP50NGM agarFUdR, penicillin, streptomycinNL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}20°CGarcia-Moreno JC, Porta de la Riva M, Martínez-Lara E, Siles E, Cañuelo A (2019) Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease. Neurobiol Aging 82, 60-68. no