Compound ID 345   (prev - next)

Name: Uncaria tomentosa, aqueous leaf extract (edit)

23 entries:
TreatmentUncaria tomentosa, aqueous leaf extractphysical functionphysiological functionhealthspan biomarkersTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLbody length / growth rateoxidative stress resistanceROS levelactivity / quantity / expression of HSPsactivity / quantity / expression of SODsactivity / quantity / expression of GSTs
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperaturechange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)notes
10 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CnonenoA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
20 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CdownyesA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
40 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CupyesA1upnoA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedown-25.58yesA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
80 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CnonenoA1up76.23yesA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedownyesA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
100 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CnonenoA1upnoA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedownnoA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
40 µg/mlwhole life; start: L1OP50liquid S-mediumEU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°CupnoA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival rateup15.2yesA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
80 µg/mlwhole life; start: L1OP50liquid S-mediumEU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°CupnoA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratenonenoA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
100 µg/mlwhole life; start: L1OP50liquid S-mediumEU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°CupyesA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedownnoA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
40 µg/mlwhole life; start: L1OP50liquid S-mediumCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CdownnoA2Azevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
80 µg/mlwhole life; start: L1OP50liquid S-mediumCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°Cdown-12.08yesA2; no change under juglone-induced stressAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
100 µg/mlwhole life; start: L1OP50liquid S-mediumCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CnonenoA2Azevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
40 µg/mlwhole life; start: L1OP50liquid S-mediumCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°Cdown-32.57yesA2; pre-exposed to jugloneAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
80 µg/mlwhole life; start: L1OP50liquid S-mediumCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CdownyesA2; pre-exposed to jugloneAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
100 µg/mlwhole life; start: L1OP50liquid S-mediumCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°Cdown-63.31yesA2; pre-exposed to jugloneAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
40 µg/mlwhole life; start: L1OP50liquid S-mediumCF1038 [daf-16(mu86)]20°CupnoA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedownyesA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
80 µg/mlwhole life; start: L1OP50liquid S-mediumCF1038 [daf-16(mu86)]20°CupnoA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedownyesA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
100 µg/mlwhole life; start: L1OP50liquid S-mediumCF1038 [daf-16(mu86)]20°CupnoA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedown-27.06yesA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
40 µg/mlwhole life; start: L1OP50liquid S-mediumTJ375 {gpIs1 [hsp-16.2p::GFP]}20°Cdown-41.77yesA2; pre-exposed to jugloneAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
80 µg/mlwhole life; start: L1OP50liquid S-mediumTJ375 {gpIs1 [hsp-16.2p::GFP]}20°Cdown-41.35yesA2; pre-exposed to jugloneAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
100 µg/mlwhole life; start: L1OP50liquid S-mediumTJ375 {gpIs1 [hsp-16.2p::GFP]}20°CdownnoA2; pre-exposed to jugloneAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no