| Treatment | Urolithin B | physical function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 5380406 | ChEMBL | pharyngeal pumping | locomotion on solid media | mean lifespan | |||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 50 µM | whole life; start: egg stage | OP50 | NGM agar | N2 (wild type) | 20°C | up | yes | A7 & A14 | up | yes | A5, A8; no significant changes at A1 | up | 36,6 | yes | Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879. | |||||||||