Compound ID 350   (prev - next)

Name: Ursolic acid (3β-Hydroxy-urs-12-en-28-oic acid) (64945) (edit)

27 entries:
TreatmentUrsolic acid (3β-Hydroxy-urs-12-en-28-oic acid)cognitive functionphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)64945ChEMBLchemotaxispharyngeal pumpingbody length / growth ratenumber of offspringreproductive total spanheat stress resistanceoxidative stress resistanceautofluorescence (age pigment / lipofuscin)triglyceride / fat / lipid contentROS levelactivity / quantity / expression of SODsactivity / quantity / expression of CTLsactivity / quantity / expression of GSTsquantity of polyQ aggregatesquantity of α-synucleinmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
25 µMwhole life; start: egg stageOP50NGM agarFUDRN2 (wild type)20°CupyesA2; stressor: 35°C; endpoint: survivalupyesA2; stressor: 100 mM paraquat; endpoint: survivalup32.48yesup-regulation of jnk-1Negi H, Shukla A, Khan F, Pandey R (2016) 3β-Hydroxy-urs-12-en-28-oic acid prolongs lifespan in C. elegans by modulating JNK-1. Biochem Biophys Res Commun 480, 539-543. no
25 µMwhole life; start: egg stageOP50NGM agarFUDRGR1307 [daf-16(mgDf50)]20°Cup28.03yesNegi H, Shukla A, Khan F, Pandey R (2016) 3β-Hydroxy-urs-12-en-28-oic acid prolongs lifespan in C. elegans by modulating JNK-1. Biochem Biophys Res Commun 480, 539-543. no
25 µMwhole life; start: egg stageOP50NGM agarFUDRVC8 [jnk-1(gk7)]20°Cup1.15noNegi H, Shukla A, Khan F, Pandey R (2016) 3β-Hydroxy-urs-12-en-28-oic acid prolongs lifespan in C. elegans by modulating JNK-1. Biochem Biophys Res Commun 480, 539-543. no
25 µMwhole life; start: egg stageOP50NGM agarFUDRKU2 [jkk-1(km2)]20°Cup3.23noNegi H, Shukla A, Khan F, Pandey R (2016) 3β-Hydroxy-urs-12-en-28-oic acid prolongs lifespan in C. elegans by modulating JNK-1. Biochem Biophys Res Commun 480, 539-543. no
25 µMwhole life; start: egg stageOP50NGM agarFUDRFK171 [mek-1(ks54)]20°Cup29.85yesNegi H, Shukla A, Khan F, Pandey R (2016) 3β-Hydroxy-urs-12-en-28-oic acid prolongs lifespan in C. elegans by modulating JNK-1. Biochem Biophys Res Commun 480, 539-543. no
25 µM48 h; start: L1OP50NGM agarCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CnonenoL4/A1; expression of sod-3; measured via fluorescenceNegi H, Shukla A, Khan F, Pandey R (2016) 3β-Hydroxy-urs-12-en-28-oic acid prolongs lifespan in C. elegans by modulating JNK-1. Biochem Biophys Res Commun 480, 539-543. no
10 µMwhole life; start: egg stageOP50NGM agarFUDRN2 (wild type)20°Cup6.20yesNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRN2 (wild type)20°CupyesA5; attractant: 1 M sodium acetatenonenoA5 and A10nonenoA5 and A10down-8.43yesup69.57yesup31.10yesA2; stressor: 35°C; endpoint: survivalup18.33yesA2; stressor: 100 mM paraquat; endpoint: survivaldown-47.07yesA2, A5, A10, and A15; blue fluorescencedown-31.52yesL4/A1down-51.15yesA2; measured via H2DCF-DAup5.29noL4/A1; SOD-activitydown-1.90noL4/A1; catalase-activityup8.90noL4/A1; GST-activityup31.30yesup-regulation of gcs-1, daf-9, jnk-1, and sir-2.1jnk-1, skn-1Negi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
50 µMwhole life; start: egg stageOP50NGM agarFUDRN2 (wild type)20°Cup0.14noNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
100 µMwhole life; start: egg stageOP50NGM agarFUDRN2 (wild type)20°CnonenoNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRN2 (wild type)15°Cup40.09yesNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRCB1370 [daf-2(e1370)]20°Cup29.40yesNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRGR1307 [daf-16(mgDf50)]20°Cup28.03yesNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRPS3551 [hsf-1(sy441)]20°Cup3.05noNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRPS3551 [hsf-1(sy441)]15°Cup37.14yesNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRVC8 [jnk-1(gk7)]20°Cup1.15noNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRKU2 [jkk-1(km2)]20°Cup3.23noNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRDA1116 [eat-2(ad1116)]20°Cup2.45noNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDREU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°Cup1.4noNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRJK1521 [fog-2(q71); pha-4(q490)/stu-3 (q265); rol-9 (sc148)]20°Cup31.24yesNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRVC199 [sir-2.1(ok434)]20°Cup15.80yesNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarFUDRTK22 [mev-1(kn1)]20°Cdown-3.77noNegi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarAM141 {rmIs133 [unc-54p::Q40::YFP]}20°Cdown-45.71yesA1; no significant changes at A5 and A7Negi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.
25 µMwhole life; start: egg stageOP50NGM agarNL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}20°Cdown-36.52yesA1; no significant changes at A5 and A7Negi H, Saikia SK, Pandey R (2017) 3β-hydroxy-urs-12-en-28-oic acid modulates dietary restriction mediated longevity and ameliorates toxic protein aggregation in C. elegans. J Gerontol A Biol Sci Med Sci, in press.