Compound ID 354 (prev - next)

Name: Verminoside (12000883) (edit)

14 entries:

Treatment	Verminoside						physical function				physiological function								healthspan biomarkers												lifespan				Target	Reference
CID (PubChem)	12000883	ChEMBL					pharyngeal pumping				heat stress resistance				oxidative stress resistance				ROS level				activity / quantity / expression of SODs				translocation of DAF-16 to nucleus				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
5 µM	whole life; start: L1	OP50	NGM agar	FUDR	N2 (wild type)	20°C																									up	9.84	yes			Pant A, Asthana J, Yadav AK, Rathor L, Srivastava S, Gupta MM, Pandey R (2015) Verminoside mediates life span extension and alleviates stress in Caenorhabditis elegans. Free Radic Res 49, 1384-1392.
25 µM	whole life; start: L1	OP50	NGM agar	FUDR	N2 (wild type)	20°C																									up	20.79	yes			Pant A, Asthana J, Yadav AK, Rathor L, Srivastava S, Gupta MM, Pandey R (2015) Verminoside mediates life span extension and alleviates stress in Caenorhabditis elegans. Free Radic Res 49, 1384-1392.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	N2 (wild type)	20°C																									up	8.54	yes			Pant A, Asthana J, Yadav AK, Rathor L, Srivastava S, Gupta MM, Pandey R (2015) Verminoside mediates life span extension and alleviates stress in Caenorhabditis elegans. Free Radic Res 49, 1384-1392.
5 µM	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C	none		no	A5 and A10	up	6.10	yes	A2; stressor: 37°C for 4 h; endpoint: survival	up	100.00	yes	A2; stressor: 250 µM juglone; endpoint: survival	down	-31.00	yes	A1/A2; measured via H2DCF-DA at 37°C														Pant A, Asthana J, Yadav AK, Rathor L, Srivastava S, Gupta MM, Pandey R (2015) Verminoside mediates life span extension and alleviates stress in Caenorhabditis elegans. Free Radic Res 49, 1384-1392.
25 µM	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C	none		no	A5 and A10	up	27.85	yes	A2; stressor: 37°C for 4 h; endpoint: survival	up	216.65	yes	A2; stressor: 250 µM juglone; endpoint: survival	down	-57.00	yes	A1/A2; measured via H2DCF-DA at 37°C													daf-16 and sod-3	Pant A, Asthana J, Yadav AK, Rathor L, Srivastava S, Gupta MM, Pandey R (2015) Verminoside mediates life span extension and alleviates stress in Caenorhabditis elegans. Free Radic Res 49, 1384-1392.
50 µM	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C	none		no	A5 and A10	up	10.79	yes	A2; stressor: 37°C for 4 h; endpoint: survival	up	116.65	yes	A2; stressor: 250 µM juglone; endpoint: survival	down	-41.00	yes	A1/A2; measured via H2DCF-DA at 37°C														Pant A, Asthana J, Yadav AK, Rathor L, Srivastava S, Gupta MM, Pandey R (2015) Verminoside mediates life span extension and alleviates stress in Caenorhabditis elegans. Free Radic Res 49, 1384-1392.
25 µM	whole life; start: L1	OP50	NGM agar	FUDR	TK22 [mev-1(kn1)]	20°C																									up	29.54	yes			Pant A, Asthana J, Yadav AK, Rathor L, Srivastava S, Gupta MM, Pandey R (2015) Verminoside mediates life span extension and alleviates stress in Caenorhabditis elegans. Free Radic Res 49, 1384-1392.
25 µM	whole life; start: L1	OP50	NGM agar	FUDR	GR1307 [daf-16(mgDf50)]	20°C																									up	1.47	no			Pant A, Asthana J, Yadav AK, Rathor L, Srivastava S, Gupta MM, Pandey R (2015) Verminoside mediates life span extension and alleviates stress in Caenorhabditis elegans. Free Radic Res 49, 1384-1392.
25 µM	whole life; start: L1	OP50	NGM agar	FUDR	CB1370 [daf-2(e1370)]	20°C																									up	1.17	no			Pant A, Asthana J, Yadav AK, Rathor L, Srivastava S, Gupta MM, Pandey R (2015) Verminoside mediates life span extension and alleviates stress in Caenorhabditis elegans. Free Radic Res 49, 1384-1392.
25 µM	whole life; start: L1	OP50	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																					up		yes	A1						Pant A, Asthana J, Yadav AK, Rathor L, Srivastava S, Gupta MM, Pandey R (2015) Verminoside mediates life span extension and alleviates stress in Caenorhabditis elegans. Free Radic Res 49, 1384-1392.
25 µM	whole life; start: L1	OP50	NGM agar		CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}	20°C																	up		yes	A1; sod-2 expression; measured via fluorescence										Pant A, Asthana J, Yadav AK, Rathor L, Srivastava S, Gupta MM, Pandey R (2015) Verminoside mediates life span extension and alleviates stress in Caenorhabditis elegans. Free Radic Res 49, 1384-1392.