Compound ID 357 (prev - next)

Name: Vitexin (from Vigna angularis) (5280441) (edit)

9 entries:

Treatment	Vitexin (from Vigna angularis)						physical function												reproductive function				physiological function								healthspan biomarkers																lifespan								Target	Reference
CID (PubChem)	5280441	ChEMBL					pharyngeal pumping				locomotion on solid media				body length / growth rate				number of offspring				heat stress resistance				oxidative stress resistance				ROS level				activity / quantity / expression of HSPs				activity / quantity / expression of SODs				activity / quantity / expression of CTLs				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
50 µM	whole life; start: egg stage	OP50	NGM agar		N2 (wild type)	20°C	none		no	A4	up		no	A4 and A7; endpoint: travel range	none		no	A4	down		no		up	17.40	yes	A4; stressor: 36°C; endpoint: mean lifespan; also increased maximum lifespan	up	20.50	yes	A7; stressor: 1mM juglone; endpoint: mean lifespan; also increased maximum lifespan	down		yes	A4; pre-exposed to juglone; measured via H2DCF-DA					up		yes	A5; SOD-activity; measured via formazan	up		yes	A5; catalase activity	up	8.00	yes		up	5.26	n.d.		SOD-3 and HSP-16.2	Lee EB, Kim JH, Cha YS, Kim M, Song SB, Cha DS, Jeon H, Eun JS, Han S, Kim DK (2015) Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 582-589.
100 µM	whole life; start: egg stage	OP50	NGM agar		N2 (wild type)	20°C	none		no	A4	up	7.50	yes	A4 and A7; endpoint: travel range	none		no	A4	down		no		up	45.80	yes	A4; stressor: 36°C; endpoint: mean lifespan; also increased maximum lifespan	up	56.20	yes	A7; stressor: 1mM juglone; endpoint: mean lifespan; also increased maximum lifespan	down	-14.60	yes	A4; pre-exposed to juglone; measured via H2DCF-DA					up		yes	A5; SOD-activity; measured via formazan	up		yes	A5; catalase activity	up	17.2	yes		up	10.53	n.d.			Lee EB, Kim JH, Cha YS, Kim M, Song SB, Cha DS, Jeon H, Eun JS, Han S, Kim DK (2015) Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 582-589.
50 µM	whole life; start: egg stage	OP50	NGM agar		CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}	20°C																																																		Lee EB, Kim JH, Cha YS, Kim M, Song SB, Cha DS, Jeon H, Eun JS, Han S, Kim DK (2015) Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 582-589.
100 µM	whole life; start: egg stage	OP50	NGM agar		CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}	20°C																																	up		yes	A3; sod-3 expression; measured via fluorescence														Lee EB, Kim JH, Cha YS, Kim M, Song SB, Cha DS, Jeon H, Eun JS, Han S, Kim DK (2015) Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 582-589.
50 µM	whole life; start: egg stage	OP50	NGM agar		CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}	20°C																																	up	25.40	yes	A3; sod-3 expression; measured via fluorescence														Lee EB, Kim JH, Cha YS, Kim M, Song SB, Cha DS, Jeon H, Eun JS, Han S, Kim DK (2015) Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 582-589.
100 µM	whole life; start: egg stage	OP50	NGM agar		CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}	20°C																													up		yes	A3; pre-exposed to 36°C; measured via fluorescence																		Lee EB, Kim JH, Cha YS, Kim M, Song SB, Cha DS, Jeon H, Eun JS, Han S, Kim DK (2015) Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 582-589.