Compound ID 360 (prev - next)

Name: Withanolide A (11294368) (edit)

24 entries:

Treatment	Withanolide A						cognitive function				physical function																reproductive function				physiological function								healthspan biomarkers																																				lifespan												Transcriptome	Reference	blinded
CID (PubChem)	11294368	ChEMBL					chemotaxis				pharyngeal pumping				locomotion in liquid media				locomotion on solid media				body length / growth rate				number of offspring				heat stress resistance				oxidative stress resistance				autofluorescence (age pigment / lipofuscin)				acetylcholine level				ROS level				triglyceride / fat / lipid content				quantity of α-synuclein				activity of acetylcholinesterase				activity / quantity / expression of SODs				activity / quantity / expression of GSTs				translocation of DAF-16 to nucleus				median lifespan				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
2 µM	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C																																																																					none		n.d.		up	4.32	yes		up	7.59	n.d.			Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C																									up	19.00		A3; stressor: 35°C for 3.5 h; endpoint: survival					down	-27.54	yes	A10; green fluorescence																																	up	21.43	n.d.		up	29.65	yes		up	45.30	n.d.		up-regulation of sgk-1, daf-16, sod-3, fkh-9, skn-1, gst-4, hsf-1, and hsp-16.2	Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
25 µM	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C																																																																					up	14.29	n.d.		up	15.79	yes		up	24.58	n.d.			Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
50 µM	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C																																																																					up	7.14	n.d.		up	10.81	yes		up	15.12	n.d.			Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20°C	up		yes	A5; attractant: NaCl	none		no	A2, A5, and A10	up		yes	A1, A3, and A5; endpoint: number of body bends					up		yes	A2, A5, and A10; length and width	down	-9.00	yes	reproduction in a 12-h time frame					up		n.d.	A6; stressor: 10 mM paraquat; endpoint: survival									down		yes	A3																																						Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar		N2 (wild type)	22°C																																					up	78.00	yes	A2													up	34.00	no	A2																										Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar	FUDR	TK22 [mev-1(kn1)]	20°C																																																																									up	15.51	yes		up	23.70	n.d.			Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar	FUDR	DA1116 [eat-2(ad1116)]	20°C																																																																									up		n.d.		up		n.d.			Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar	FUDR	VC345 [sgk-1(ok538)]	20°C																																																																									up	2.68	yes		up	6.43	n.d.			Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar	FUDR	PS3551 [hsf-1(sy441)]	20°C																																																																									up	4.50	yes		none		n.d.			Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar	FUDR	GR1307 [daf-16(mgDf50)]	20°C																																																																									down	-2.24	yes		down	-3.23	n.d.			Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar	FUDR	EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]	20°C																																																																									down	-3.75	yes		down	-3.03	n.d.			Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																																																																	none		no	A3														Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar		CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}	20°C																																																													up		yes	A3; gst-4 expression; measured via fluorescence																		Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar		CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}	20°C																																																									up		yes	A3; sod-3 expression; measured via fluorescence																						Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar		CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	15°C													up	51.40	yes	A2; pre-exposure at 25°C; endpoint: ratio of non-paralyzed and paralyzed worms																																																																		Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar		NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}	20°C																																																	down	-38.00	yes	A3																														Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol 78, 47-56.	no
5 µM	whole life; start: L4	OP50	NGM agar	FUdR	N2 (wild type)	20°C																																													down	-11	yes	A3																									up	27,7	yes							Akhoon, B. A., Rathor, L., & Pandey, R. (2018). Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. Experimental gerontology, 104, 113-117.
5 µM	whole life; start: L4	OP50	NGM agar	FUdR	JG337 {let-23(sy1); jgls[let-23N::hEGFR-C; rol-6d]}	15°C																																													down	-14,6	yes	A3																									up	20,4	yes							Akhoon, B. A., Rathor, L., & Pandey, R. (2018). Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. Experimental gerontology, 104, 113-117.
5 µM	whole life; start: L4	OP50	NGM agar	FUdR	JG324 {sqt-1(jg52); jgls6 [let-23::hEGFR-TK(L858R); rol-6d]}	15°C																																													down	-17,2	yes	A3																									up	24,2	yes							Akhoon, B. A., Rathor, L., & Pandey, R. (2018). Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. Experimental gerontology, 104, 113-117.
5 µM	whole life; start: L4	OP50	NGM agar	FUdR	JG388 {sqt-1(jg52); jgls25 [let-23::hEGFR-TK(T790M-L858R); rol-6d; myo2::mCherry]}	15°C																																													down	-13,2	yes	A3																									up	21,3	yes							Akhoon, B. A., Rathor, L., & Pandey, R. (2018). Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. Experimental gerontology, 104, 113-117.