Compound ID 362 (prev - next)

Name: α,α-Trehalose (7427) (edit)

25 entries:

Treatment	α,α-Trehalose						physical function								reproductive function								physiological function				healthspan biomarkers								lifespan								Reference	blinded
CID (PubChem)	7427	ChEMBL					pharyngeal total span				pharyngeal pumping				number of offspring				reproductive total span				heat stress resistance				autofluorescence (age pigment / lipofuscin)				quantity of polyQ aggregates				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
1 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUdR	N2 (wild type)	20 °C																													up	24	yes		up	28	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUdR	N2 (wild type)	20 °C	up	50	n.d.		up		n.d.	A6 - A39; change is increasing with increasing age									up		yes	A1; stressor: 35°C until death; endpoint: mean lifespan. No increased survival when stress was stopped after 8.5 h	down		n.d.	A26 (control) vs A32 (treated); blue fluorescence					up	32	yes	in other trials: only +27%	up	41,2	n.d.	in other trials: only +15%	Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
10 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUdR	N2 (wild type)	20 °C																													up	19	yes		up	18	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar		N2 (wild type)	20 °C									up	10	yes		up	39,2	yes	mean reproductive span; maximum reproductive span: +50%																					Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: A10	OP50, UV-inactivated	NGM agar	FUdR	N2 (wild type)	20 °C																													up	37	yes	percentual change is given for the remaining life time after start of treatment	up	20,6	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: A15	OP50, UV-inactivated	NGM agar	FUdR	N2 (wild type)	20 °C																													up	44	yes	percentual change is given for the remaining life time after start of treatment	up	14,7	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: A20	OP50, UV-inactivated	NGM agar	FUdR	N2 (wild type)	20 °C																													up	60	yes	percentual change is given for the remaining life time after start of treatment	up	11,8	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	start: L4; stop: A10	OP50, UV-inactivated	NGM agar	FUdR	N2 (wild type)	20 °C																													none		no		down	-5,4	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	start: A10; stop: A20	OP50, UV-inactivated	NGM agar	FUdR	N2 (wild type)	20 °C																													up	10	yes	percentual change is given for the remaining life time after start of treatment	down	-2,7	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	OP50	NGM agar	FUdR	N2 (wild type)	20 °C																													up	12	yes		up	3	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L1	OP50, UV-inactivated	NGM agar	FUdR	unknown strain; genotype: [polyQ40::YFP]	20 °C																									down		yes	L1-A4; several measurements									Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: A10	OP50, UV-inactivated	NGM agar	FUdR	unknown strain; genotype: [polyQ40::YFP]	20 °C																									none		no	A15									Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM		OP50, UV-inactivated	NGM agar	FUdR	unknown strain; genotype: [polyQ40::YFP]	20 °C																																					Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUdR	CB1370 [daf-2(e1370)]	20 °C																													none		no		down	-2	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUdR	DR1572 [daf-2(e1368)]	20 °C																													up	3	no		up	2	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUdR	GR1309 [daf-16(mgDf47); daf-2(e1370)]	20 °C																													up	11	yes		up	30	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUdR	unknown strain [daf-16(mgDf47)]	20 °C																													up	11	yes		up	29	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUdR	CB1372 [daf-7(e1372)]	20 °C																													up	21	yes		up	69	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	HT115 (DE3)	NGM agar	FUdR	N2 (wild type)	20 °C																													up	11	yes		up	16	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	HT115 (DE3) with RNAi-vector against tps-1 & tps-2	NGM agar	FUdR	N2 (wild type)	20 °C																													up	12,3	yes		up	11,8	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	HT115 (DE3)	NGM agar	FUdR	CB1370 [daf-2(e1370)]	20 °C																													up	1	no		down	-11	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no
5 mM	whole life; start: L4	HT115 (DE3) with RNAi-vector against tps-1 & tps-2	NGM agar	FUdR	CB1370 [daf-2(e1370)]	20 °C																													up	14,8	yes		up	25	n.d.		Honda, Y., Tanaka, M., & Honda, S. (2010). Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging cell, 9(4), 558-569.	no