Compound ID 364   (prev - next)

Name: α-Tocopherol (14985) (edit)

6 entries:
Treatmentα-Tocopherolphysiological functionhealthspan biomarkersTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)14985ChEMBLheat stress resistanceUV stress resistanceROS level
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
160 µMwhole life; start: A1OP50NGM agarN2 (wild type)20°Cdown-8.93variableA2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan; significantly decreased survival in two trials, unchanged survival (not significant) in one trial; percentual change = average of 3 trialsBenedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
4 mMwhole life; start: A1OP50NGM agarN2 (wild type)20°CvariablevariableA2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan; significantly decreased survival in one trial, increased survival (not significant) in two trialsBenedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
10 µg/mlwhole life; start: L4OP50NGM agarN2 (wild type)20°Cupn.d.stressor: UV-A; medium: M9 buffer; endpoint: survival ratedownyesmeasurement via DCF-DA and after UV-A stressAlexpandi R, Prasanth MI, Ravi AV, Balamurugan K, Durgadevi R, Srinivasan R, De Mesquita JF, Pandian SK (2019) Protective effect of neglected plant Diplocyclos palmatus on quorum sensing mediated infection of Serratia marcescens and UV-A induced photoaging in model Caenorhabditis elegans. J Photochem Photobiol B 201, 111637. no