Compound ID 365 (prev - next)

Name: α-lipoic acid (864) (edit)

20 entries:

Treatment	α-lipoic acid						cognitive function				physical function								reproductive function								physiological function				healthspan biomarkers																lifespan												Reference
CID (PubChem)	864	ChEMBL					chemotaxis				pharyngeal pumping				locomotion on solid media				number of offspring				quantity of early reproduction				heat stress resistance				ROS level				activity / quantity / expression of SODs				activity / quantity / expression of GSTs				activity / quantity / expression of CYPs				median lifespan				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
47 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C																					down	-13.26	variable	A2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan; 1 out of 2 trials were significant; percentual change = average of 2 trials																													Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
200 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C																					up	6.13	variable	A2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan; 2 out of 3 trials were significant; percentual change = average of 3 trials																	none		yes	The curves significantly differ from each other despite identical median values					up	6.76	n.d.	90th percentile survival	Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
233 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C																					up	16.67	variable	A2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan; 1 out of 2 trials were significant; percentual change = average of 2 trials																													Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
1 mM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C													down	-9.97	no		down	-17.00	yes; first 48 h		up	36.67	yes	A2; Stressor: 35°C; stress exposure in S-medium; endpoint: median lifespan; percentual change = average of 5 trials																	up	21.00	yes	Significant changes in 5 of 6 trials					variable		n.d.	90th percentile survival	Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
50 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C																																									up	6.67	no	only 1 trial					down	-3.88	n.d.	90th percentile survival; only 1 trial	Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
100 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C																																									up	6.67	no	only 1 trial					up	9.63	n.d.	90th percentile survival; only 1 trial	Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
500 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C													down	-4.18	no																																						Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
5 mM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C																																									down	-21.43	yes	only 1 trial					down	-29.28	n.d.	90th percentile survival; only 1 trial	Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
1 mM	whole life; start: A1	OP50	NGM agar		CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}	20°C																																	down		no	A2; measured via fluorescence																	Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
1 mM	whole life; start: A1	OP50	NGM agar		CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}	20°C																													none		no	A2; measured via fluorescence																					Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
1 mM	whole life; start: A1	OP50	NGM agar		unknown strain [cyp-35::GFP]	20°C																																					down		no	A2; measured via fluorescence													Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43, 882-891.
10 µM	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C					none		no	A2, A4, A6, A8																	down		no	L4/A1, measurement via DCF-DA																									Brown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
25 µM	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C	up		yes	A5; no significant changes at A1; attractant: diacetyl	none		no	A2, A4, A6, A8	none		no	A12, A16;													down		yes	L4/A1; no significant changes at A5; measurement via DCF-DA																	up	24,2	yes		up	14,3	yes		Brown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
50 µM	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C					none		no	A2, A4, A6, A8																	down		yes	L4/A1, measurement via DCF-DA																									Brown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
100 µM	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C					none		no	A2, A4, A6, A8																	down		yes	L4/A1, measurement via DCF-DA																									Brown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
25 µM	whole life; start: L1	OP50	NGM agar		GR1307 [daf-16(mgDf50)]	20°C																									down		yes	L4/A1, measurement via DCF-DA																	none	6,8	no		none	0	no		Brown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
25 µM	whole life; start: egg stage	OP50	NGM agar		CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C									none		no	L3; temperature shift to 23°C prior analysing paralysis																																									Brown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.