Compound ID 366 (prev - next)

Name: Ascarosides ascr#3 & ascr#2 mixture (edit)

12 entries:

Treatment	Ascarosides ascr#3 & ascr#2 mixture						physical function				physiological function				lifespan				Target	Reference
CID (PubChem)							pharyngeal pumping				oxidative stress resistance				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
1 nM (from each substance)	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C					up		n.d.	A1; stressor: 0.6 mM H2O2; endpoint: survival					DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
250 nM (from each substance)	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C					up		n.d.	A1; stressor: 0.6 mM H2O2; endpoint: survival					DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
500 nM (from each substance)	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C					up		n.d.	A1; stressor: 0.6 mM H2O2; endpoint: survival					DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
0.75 µM (from each substance)	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C									up	12,5	yes		DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
1 µM (from each substance)	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C	up		yes	A 5 until death; no significant changes in younger worms	up		n.d.	A1; stressor: 0.6 mM H2O2; endpoint: survival	up	14,9	yes		DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
1.25 µM (from each substance)	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C									up	22,6	yes		DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
1.5 µM (from each substance)	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C					up		n.d.	A1; stressor: 0.6 mM H2O2; endpoint: survival					DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
3 µM (from each substance)	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C									up	10,7	yes		DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
5 µM (from each substance)	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C					up		n.d.	A1; stressor: 0.6 mM H2O2; endpoint: survival					DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.