Treatment | Boeravinone B | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | 14018348 | ChEMBL | | | | | pharyngeal pumping | | | | locomotion in liquid media | | | | number of offspring | | | | vertex (progeny per day) | | | | heat stress resistance | | | | oxidative stress resistance | | | | autofluorescence (age pigment / lipofuscin) | | | | ROS level | | | | activity / quantity / expression of CTLs | | | | activity / quantity / expression of SODs | | | | GSH level | | | | activity / quantity / expression of GSTs | | | | activity / quantity / expression of HSPs | | | | translocation of DAF-16 to nucleus | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
5 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | up | | yes | A3; stressor: 35°C for 3.5 h; endpoint: survival | up | | yes | A6; stressor: 10 mM paraquat; endpoint: survival | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 17,1 | yes | hier | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | down | | yes | A5, A10 | up | | yes | A5, A10 | | | | | | | | | | | | | | | | | down | -32,9 | yes | A10; blue fluorescence | down | -45,7 | yes | A2; similar result at A5; measured via DCF-DA | up | | yes | | up | | yes | | down | | yes | | | | | | | | | | | | | | up | 27,6 | yes | hier | upregulation of pdk-1, daf-16, skn-1, hsp-70, hsp-16.2, jnk-1, pmk-1, sek-1, mek-1, sod-1, sod-2, sod-3, gst-4, gst-7, ctl-1, ctl-2, eat-2 | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
50 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 15,3 | yes | hier | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | down | | yes | | down | | yes | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | TK22 [mev-1(kn1)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 14,8 | yes | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | CW152 [gas-1(fc21)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 16,1 | yes | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | CB1370 [daf-2(e1370)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 2,5 | yes | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | TJ1052 [age-1(hx546)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 3,7 | no | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | GR1307 [daf-16(mgDf50)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -3,6 | no | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -0,4 | no | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | KU4 [sek-1(km4)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -2,8 | no | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | RB754 [aak-2(ok524)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -4,5 | yes | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | DA1116 [eat-2(ad1116)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 4 | no | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | GST-4 | | | | | | | | | | | | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | SOD-3 | | | | | | | | | | | | | | | | | | | | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | HSP-16.2 | | | | | | | | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |
25 µM | whole life; start: L1 | OP50 | NGM agar | FUdR | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | n.d. | | | | | | | | | | Rathor, L., & Pandey, R. (2018). Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Experimental gerontology, 111, 94-106. | no |