Treatment | Chicoric acid | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||||||||
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CID (PubChem) | ChEMBL | pharyngeal pumping | locomotion on solid media | body length / growth rate | number of offspring | speed of larval development | vertex (progeny per day) | oxidative stress resistance | ROS level | translocation of SKN-1 to nucleus | median lifespan | |||||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | ||||||
12.5 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | none | no | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | ||||||||||||||||||||||||||||||||||||||||||
25 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | up | 29.1 | yes | A11; similar at A5-A9; no significant changes at A1 & A3 | up | 59 | yes | A11; similar at A3-A9; no significant changes at A1 | none | no | L4/A1; worm width and worm length | up | 20.8 | yes | A1; stressor: 5 mM paraquat; endpoint: survival at A7 (similar at A3 and A5) | down | -14.6 | yes | A1; measurement via DCF-DA | up | 21.05 | yes | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | ||||||||||||||||||||||
50 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | up | 32.9 | yes | A11; similar at A5-A9; no significant changes at A1 & A3 | up | 86 | yes | A11; similar at A3-A9; no significant changes at A1 | none | no | L4/A1; worm width and worm length | down | -19.2 | yes | A1; measurement via DCF-DA | up | 15.79 | yes | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | ||||||||||||||||||||||||||
25 μM | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | none | no | none | no | A1; upregulation of aak-2, nhr-49, skn-1, gsr-1, sbp-5 | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | ||||||||||||||||||||||||||||||||||||||
50 μM | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | none | no | none | no | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||
25 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | RB754 [aak-2(ok524)] | 20°C | none | no | A1; stressor: 5 mM paraquat; endpoint: survival at A3, A5, A7 | none | no | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||
50 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | RB754 [aak-2(ok524)] | 20°C | up | 16.67 | no | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||||
25 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | CB1370 [daf-2(e1370)] | 15°C | up | 12.5 | yes | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||||
50 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | CB1370 [daf-2(e1370)] | 15°C | up | 18.75 | yes | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||||
25 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | DA1116 [eat-2(ad1116)] | 20°C | down | -25 | yes | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||||
50 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | DA1116 [eat-2(ad1116)] | 20°C | down | -18.75 | yes | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||||
25 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | GR1307 [daf-16(mgDf50)] | 20°C | up | 28.57 | yes | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||||
50 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | GR1307 [daf-16(mgDf50)] | 20°C | up | 42.86 | yes | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||||
25 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]] | 20°C | up | 12.5 | no | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||||
50 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]] | 20°C | up | 12.5 | no | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||||
25 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | TJ1052 [age-1(hx546)] | 20°C | up | 14.29 | yes | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||||
50 μM | whole life; start: L4 | OP50 | NGM agar | FUdR | TJ1052 [age-1(hx546)] | 20°C | up | 14.29 | yes | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no | |||||||||||||||||||||||||||||||||||||||||
25 μM | whole life; start: L4 | OP50 | NGM agar | LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]} | 20°C | up | yes | L4/A1 | Peng Y, Sun Q, Gao R, Park Y (2019) AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans. J Agric Food Chem 67, 9178-9186. | no |