Treatment | Dipeptide Tyr-Ala | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||||||||||||||||||||||||||||
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CID (PubChem) | 4078684 | ChEMBL | locomotion in liquid media | heat stress resistance | oxidative stress resistance | autofluorescence (age pigment / lipofuscin) | triglyceride / fat / lipid content | ROS level | activity / quantity / expression of HSPs | activity / quantity / expression of SODs | mean lifespan | maximum lifespan | ||||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
1 mM | whole life; start: A1 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | no | A5 | up | n.d. | A3; stressor: 35°C; endpoint: mean lifespan | up | 13.53 | yes | A3; stressor: 500 µM juglone; endpoint: mean lifespan | down | yes | A 10; blue fluorescence | down | yes | A5 | up | 10.37 | yes | up | 13.04 | n.d. | Zhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, Guo Y, Xu L, Zhao B (2016) The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct 7, 1975-1984. | yes | ||||||||||||||||||||||
10 mM | whole life; start: A1 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | yes | A5 | up | 35.49 | yes | A3; stressor: 35°C; endpoint: mean lifespan | up | 40.58 | yes | A3; stressor: 500 µM juglone; endpoint: mean lifespan | down | -54.66 | yes | A 10; blue fluorescence | down | -39.68 | yes | A5 | down | yes | A3; measured via H2DCF-DA; similar change when pre-exposed to 300 µM juglone for 1 h | up | 12.43 | yes | up | 13.04 | n.d. | down-regulation of daf-2; up-regulation of daf-16, sod-3, hsp-16.2, and skn-1 | Zhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, Guo Y, Xu L, Zhao B (2016) The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct 7, 1975-1984. | yes | |||||||||||||||
10 mM | whole life; start: A1 | OP50 | NGM agar | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | up | 45.20 | yes | A3; pre-exposed to 300 µM juglone for 1 h | Zhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, Guo Y, Xu L, Zhao B (2016) The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct 7, 1975-1984. | yes | |||||||||||||||||||||||||||||||||||||||||
10 mM | whole life; start: A1 | OP50 | NGM agar | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20°C | up | 57.20 | yes | A4; pre-exposed to 25°C/30°C for 30 min and 35°C for 1 h; measured via fluorescence | Zhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, Guo Y, Xu L, Zhao B (2016) The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct 7, 1975-1984. | yes |