Compound ID 383   (prev - next)

Name: Dipeptide Tyr-Ala (4078684) (edit)

7 entries:
TreatmentDipeptide Tyr-Alaphysical functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)4078684ChEMBLlocomotion in liquid mediaheat stress resistanceoxidative stress resistanceautofluorescence (age pigment / lipofuscin)triglyceride / fat / lipid contentROS levelactivity / quantity / expression of HSPsactivity / quantity / expression of SODsmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
1 mMwhole life; start: A1OP50NGM agarFUDRN2 (wild type)20°CupnoA5upn.d.A3; stressor: 35°C; endpoint: mean lifespanup13.53yesA3; stressor: 500 µM juglone; endpoint: mean lifespandownyesA 10; blue fluorescencedownyesA5up10.37yesup13.04n.d.Zhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, Guo Y, Xu L, Zhao B (2016) The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct 7, 1975-1984. yes
10 mMwhole life; start: A1OP50NGM agarFUDRN2 (wild type)20°CupyesA5up35.49yesA3; stressor: 35°C; endpoint: mean lifespanup40.58yesA3; stressor: 500 µM juglone; endpoint: mean lifespandown-54.66yesA 10; blue fluorescencedown-39.68yesA5downyesA3; measured via H2DCF-DA; similar change when pre-exposed to 300 µM juglone for 1 hup12.43yesup13.04n.d.down-regulation of daf-2; up-regulation of daf-16, sod-3, hsp-16.2, and skn-1Zhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, Guo Y, Xu L, Zhao B (2016) The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct 7, 1975-1984. yes
10 mMwhole life; start: A1OP50NGM agarCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°Cup45.20yesA3; pre-exposed to 300 µM juglone for 1 hZhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, Guo Y, Xu L, Zhao B (2016) The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct 7, 1975-1984. yes
10 mMwhole life; start: A1OP50NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°Cup57.20yesA4; pre-exposed to 25°C/30°C for 30 min and 35°C for 1 h; measured via fluorescenceZhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, Guo Y, Xu L, Zhao B (2016) The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct 7, 1975-1984. yes