100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | N2 (wild type) | 20°C | down | | yes | A3, A9, A12; unchanged at A6 | up | | yes | A9, A12; no significant changes at A6, A15, A18 | | | | | up | | yes | A1; stressor: 5 nM or 7.5 mM sodium arsenite; endpoint: survival | | | | | | | | | | | | | | | | | up | 19,2 | yes | no significance in 2 out of 8 single trials | up | 18 | yes | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin | N2 (wild type) | 20°C | | | | | | | | | down | | yes | | | | | | | | | | | | | | | | | | | | | | up | 20 | yes | | | | | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | 12 h; start: A1 | OP50-1, heat-inactivated | NGM agar | streptomycin | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | A1; upregulation of dlg-1, magu-3 | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR, N-acetyl-cysteine | N2 (wild type) | 20°C | none | | no | A3 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | DR26 [daf-16(m26)] | 20°C | none | | no | A3 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | no significance in 1 out of 5 single trials | up | 7 | yes | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]] | 20°C | down | | yes | A3 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | | none | | no | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | CB4876 [clk-1(e2519)] | 20°C | up | | yes | A3 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | | up | 28,5 | yes | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | RB754 [aak-2(ok524)] | 20°C | down | | yes | A3 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | | up | 26,5 | yes | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | A3 | | | | | | | | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | SJ4005 {zcIs4 [hsp-4::GFP]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | down | | no | A3 | | | | | | | | | | | | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | SJ4100 {zcls13 [hsp-6::GFP]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | down | | no | A3 | | | | | | | | | | | | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]} | 20°C | | | | | | | | | | | | | | | | | | | | | none | | no | A3 | | | | | | | | | | | | | | | | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | PD8753 {dcr-1(ok247); hT2 [bli-4(e937) let-?(q782) qIs48]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | | none | | no | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | VC446 [alg-1(gk214)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | | none | | no | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | WM49 [rde-4(ne301)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | | up | 12 | yes | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | VC347 [mir-57(gk175)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | | | | | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | MT16848 [mir-249(n4983)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | | | | | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | VC328 [mir-47(gk167)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | no significance in 1 out of 5 single trials | | | | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | VC1051 [mir-34(gk437)] | 20°C | up | | yes | A9; unchanged at A3, A6, A12, and when adding N-acetyl-cysteine | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | | yes | | | | | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | none | | no | A3 | | | | | | | | | | | | | | | | | | | | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |
100 µg/ml | whole life; start: L4 | OP50-1, heat-inactivated | NGM agar | streptomycin, FUdR | BB4 [adr-1(gv6); adr-2(gv42)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | | none | | no | | | | | | Pinto, S., Sato, V. N., De-Souza, E. A., Ferraz, R. C., Camara, H., Pinca, A. P. F., ... & Parmigiani, R. B. (2018). Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox biology, 18, 84-92. | |