| Treatment | Ginsenoside Rg1 | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | pharyngeal pumping | locomotion on solid media | body length / growth rate | number of offspring | oxidative stress resistance | heat stress resistance | autofluorescence (age pigment / lipofuscin) | mean lifespan | |||||||||||||||||||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | ||||||
| 150 µg/ml | whole life; start: n.d. | OP50 | NGM agar | N2 (wild type) | 20°C | up | n.d. | A4 | up | n.d. | A7 | up | n.d. | A4 | none | no | up | n.d. | A4; stressor: H2O2; endpoint: mean survival | up | n.d. | A4; stressor: 37°C; endpoint: mean survival | down | n.d. | A10; green fluorescence | up | 8.8 | yes | Zeng L, Sun C, Pei Z, Yun T, Fan S, Long S, Wu T, Chen Z, Yang Z, Xu F (2019) Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO. Biogerontology 20, 665-676. | no | ||||||||||||||