Treatment | Xyloketal, derivate 31 | physiological function | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | chEMBL | heat stress resistance | ||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
100 µM | whole life; start: L1 | OP50 | NGM agar | N2 (wild type) | 20°C | up | yes | A1; stressor: 37°C; endpoint: survival | Zhou, J. B., Zheng, Y. L., Zeng, Y. X., Wang, J. W., Pei, Z., & Pang, J. Y. (2018). Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans. European journal of medicinal chemistry, 148, 63-72. |