Compound ID 390   (prev - next)

Name: Glutaredoxin from recombinant buckwheat (9501) (edit)

11 entries:
TreatmentGlutaredoxin from recombinant buckwheatphysical functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)9501ChEMBLpharyngeal pumpinglocomotion on solid mediaheat stress resistanceoxidative stress resistanceautofluorescence (age pigment / lipofuscin)ROS levelactivity / quantity / expression of CTLsactivity / quantity / expression of SODsMDA levelGSH levelmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
1 µMwhole life; start: L4OP50NGM agarN2 (wild type)20°Cup87,5yesA10; +26.7% at A5up20,7yesA10; +9% at A5upn.d.A2; stressor: 35°C; endpoint: survivalupyesA2; stressor: 240 µM juglone; endpoint: survivaldownyesA2; measured via DCF-DAupyesA2upyesA2downyesA2upyesA2up8,5yesLi, F., Ma, X., Cui, X., Li, J., & Wang, Z. (2018). Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans. Experimental gerontology, 104, 86-97.yes
2 µMwhole life; start: L4OP50NGM agarN2 (wild type)20°Cupn.d.A2; stressor: 35°C; endpoint: survivalupyesA2; stressor: 240 µM juglone; endpoint: survivaldownyesA2; measured via DCF-DAupyesA2upyesA2downyesA2upyesA2up15,6yesLi, F., Ma, X., Cui, X., Li, J., & Wang, Z. (2018). Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans. Experimental gerontology, 104, 86-97.yes
4 µMwhole life; start: L4OP50NGM agarN2 (wild type)20°CupyesA2; stressor: 35°C; endpoint: survivalupyesA2; stressor: 240 µM juglone; endpoint: survival; similar results with 10 mM H2O2downyesA10; green fluorescencedownyesA2; with and without juglone-stress; measured via DCF-DAupyesA2upyesA2downyesA2upyesA2up22yesA2; upregulation of hsf-1, hsp-16.2, hsp-70; downregulation of skn-1Li, F., Ma, X., Cui, X., Li, J., & Wang, Z. (2018). Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans. Experimental gerontology, 104, 86-97.yes
4 µMwhole life; start: L4OP50NGM agarPS3551 [hsf-1(sy441)]20°CnonenoLi, F., Ma, X., Cui, X., Li, J., & Wang, Z. (2018). Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans. Experimental gerontology, 104, 86-97.yes
4 µMwhole life; start: L4OP50NGM agarEU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°CupyesLi, F., Ma, X., Cui, X., Li, J., & Wang, Z. (2018). Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans. Experimental gerontology, 104, 86-97.yes
4 µMwhole life; start: L4OP50NGM agarCF1038 [daf-16(mu86)]20°CupyesLi, F., Ma, X., Cui, X., Li, J., & Wang, Z. (2018). Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans. Experimental gerontology, 104, 86-97.yes
4 µMwhole life; start: L4OP50NGM agarCB1370 [daf-2(e1370)]20°CupyesLi, F., Ma, X., Cui, X., Li, J., & Wang, Z. (2018). Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans. Experimental gerontology, 104, 86-97.yes
4 µMwhole life; start: L4OP50NGM agarTJ1052 [age-1(hx546)]20°CupyesLi, F., Ma, X., Cui, X., Li, J., & Wang, Z. (2018). Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans. Experimental gerontology, 104, 86-97.yes